Contraindications to Hormonal Contraception Among Postpartum Women in Texas : Obstetrics & Gynecology

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Contents: Original Research

Contraindications to Hormonal Contraception Among Postpartum Women in Texas

Coleman-Minahan, Kate PhD, FNP-BC; Ela, Elizabeth J. PhD; White, Kari PhD, MPH; Grossman, Daniel MD

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Obstetrics & Gynecology 137(5):p 907-915, May 2021. | DOI: 10.1097/AOG.0000000000004347
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Hormonal contraception is an effective way to prevent pregnancy and, for almost all people, is safer than pregnancy.1 However, some people have health conditions that may increase the risk of adverse events when using hormonal contraception. In addition, some take medications that may be affected by hormonal contraception or reduce the efficacy of their method.2,3 Limited prior research has reported that the prevalence of contraindications to combined hormonal contraception is between 2% and 16%4–7 among the general population, but is higher (39%) in a study of reproductive-aged Latina women in Texas.8 The prevalence of contraindications to progestin-only methods is low (1.7%).9

The postpartum period is typically considered a key moment to identify an appropriate contraceptive method to reduce the health risks associated with short inter-pregnancy intervals (less than 18 months between delivery and conception) for those who plan to delay a subsequent pregnancy.10 Many patients initiate a hormonal method after delivery,10–12 yet we know little about contraindications to these methods among postpartum women. People may develop health problems during pregnancy that result in new contraindications, such as hypertension or venous thromboembolism. Additionally, pregnancy-related care provides an opportunity to identify chronic illnesses among people who may have been uninsured before pregnancy and had limited access to health screenings.

Using data from a prospective cohort study of low-income postpartum women, we examined the prevalence of contraindications to combined hormonal contraception and progestin-only methods using the Centers for Disease Control and Prevention’s (CDC) 2016 Medical Eligibility Criteria for Contraceptive Use,3 factors associated with having a contraindication, and the proportion of women using a contraindicated method 6 months after delivery.


We used data from the Texas Postpartum Contraception Study (2014–2018), a 2-year prospective cohort of 1,700 women recruited after delivery at eight Texas hospitals. After obtaining informed consent, baseline interviews were conducted in person before hospital discharge, and follow-up telephone interviews were conducted at 3, 6, 12, 18, and 24 months after delivery. Participants were between the ages of 18 and 44 years, lived in Texas, spoke English or Spanish, delivered a healthy singleton neonate, were covered by public insurance or had no insurance at delivery, and wished to delay childbearing for 2 years or longer. In this analysis, we include data from the baseline and 6-month interviews. Full study procedures are reported elsewhere.12 The authors' and hospitals' institutional review boards approved the study.

In the baseline interview, participants self-reported their age, race and ethnicity, country of birth, education, and number of living children. At the 6-month interview, we asked participants whether they had attended a postpartum visit and what type of health insurance they had, if any, and they self-reported their height and weight, which we used to calculate body mass index (BMI, calculated as weight in kilograms divided by height in meters squared). We asked about the method of contraception participants were using at the time of the 6-month interview: 1) combined hormonal contraception (pill, patch, or ring), 2) depot medroxyprogesterone acetate (DMPA), 3) implant, 4) levonorgestrel intrauterine device (IUD), 5) copper IUD, 6) male or female sterilization, 7) less effective methods (condoms, withdrawal, fertility awareness–rhythm methods, spermicide, emergency contraception, and abstinence), or no method. We were unable to differentiate between combined hormonal and progestin-only pills, so we categorized all pills as combined hormonal contraception. Participants who were pregnant at the 6-month interview were not asked about current contraceptive use and are missing on this variable.

We asked participants about 19 medical conditions associated with category 3 or 4 contraindications to hormonal contraception and asked them to list all medications they were currently taking (Table 1). Contraindications were primarily assessed at the 6-month interview, except for migraine headaches and cancer, which we assessed at the 3-month interview, and hypertension, which we assessed at the 3- and 6-month interviews. If participants did not complete the interview where a question was asked, we assessed the condition at the subsequent completed interview.

Table 1.:
U.S. Medical Eligibility Criteria for Contraceptive Use and Corresponding Measures in the Texas Postpartum Contraception Study
Table 1-A.:
U.S. Medical Eligibility Criteria for Contraceptive Use and Corresponding Measures in the Texas Postpartum Contraception Study

We classified each medical condition and drug interaction according the CDC Medical Eligibility Criteria3 for combined hormonal contraception and progestin-only methods. These instances are noted in Table 1. When the CDC Medical Eligibility Criteria3 differed among combined hormonal contraceptive methods, we identified contraindications to oral contraceptive pills because they are the most commonly used combined hormonal contraceptives.

Our primary outcomes were having a contraindication to a combined hormonal contraceptive method and having a contraindication to a progestin-only method. We categorized participants as having no contraindication to each method class, having a category 3 contraindication, defined as “a condition for which the theoretical or proven risks usually outweigh the advantages of using the method,”3 or having a category 4 contraindication, defined as “a condition that represents an unacceptable health risk if the contraceptive method is used.”3 Participants who reported hypertension at either the 3- or 6-month interview were considered to have hypertension. For participants who were pregnant at the 6-month interview, we did not consider pregnancy as a contraindication and, instead, assessed whether they had any contraindication other than pregnancy. Although classification of certain medical conditions depends on the severity of symptoms, we did not capture information about severity in our data. Therefore, we treated these conditions as category 4 contraindications. We also created an indicator for having any category 3 or 4 contraindication to a hormonal contraceptive method.

As a first step in the analysis, we calculated the number and percentage of participants with each medical condition. We then calculated the percentage of participants with a category 3 contraindication only, any category 4 contraindication, and any category 3 or 4 contraindication to combined hormonal contraception and DMPA, progestin-only pills, and the implant separately and combined. Next, we examined factors associated with having any contraindication to hormonal contraception. Because maternal morbidity and mortality13,14 and contraceptive access vary by race, ethnicity, and nativity,12,15 we used self-identified race and ethnicity and nativity to create a composite variable, combining White and other races (ie, Asian American, Native American, or self-identified “other”) due to small sample sizes. We included a category for missing BMI for the 111 (7.6%) participants with missing BMI data. Participants with missing BMI were more likely than those without missing information to be older, have more children, have no health insurance, be foreign-born Hispanic, and have less education.

We used mixed-effects Poisson regression models to account for clustering by hospital. Models controlled for age (18–24, 25–29, 30 or older), race, ethnicity and nativity (Hispanic U.S.-born, Hispanic foreign-born, Black, and White or other), education (less than high school, high school diploma, more than high school), number of living children (one, two, three or more), BMI (underweight or normal weight [lower than 25], overweight [25–29.9], obese [30 or higher], missing), having any health insurance at 6 months postpartum, and attended a postpartum visit. Finally, we calculated the proportion of women using a contraindicated method at 6 months after delivery among those with a contraindication to combined hormonal contraceptive methods and progestin-only methods. Missing data (less than 1% for all variables other than BMI) were addressed using list-wise deletion. We used Stata 15 for data analysis.


Of the 1,700 women enrolled in the study, 1,452 (85.4%) completed the 6-month survey and were included in these analyses. The most commonly reported contraindications included migraine with aura (12.4%), hypertension (4.8%), and gall bladder disease (1.7%); all other contraindications were reported by less than 1.0% of the sample (Table 2). Among participants, 19.1% (278/1,452) had any category 3 or 4 contraindication to combined hormonal contraception (2.3% [34/1,452] category 3 only), and 5.4% (78/1,452) had any category 3 or 4 contraindication to DMPA (5.3% [77/1,452] category 3 only). Only 0.8% (11/1,452) of the sample had any category 3 or 4 contraindication to progestin-only pills and 0.6% (9/1,452) to the implant. A total of 19.1% (278/1,452) of the sample had any contraindication to hormonal contraception (2.3% [34/1,452] category 3 only).

Table 2.:
Prevalence of Contraindications to Hormonal Contraception 6 Months After Delivery (N=1,452)

The prevalence of any contraindication was higher among participants aged 30 years or older than among women aged 18–24 (prevalence ratio 1.45, 95% CI 1.21–1.73), was higher among participants who were overweight (prevalence ratio 1.39, 95% CI 1.07–1.80) or obese (prevalence ratio 1.55, 95% CI 1.16–2.07) compared with women who were underweight or of normal weight, and was higher among participants who were insured (prevalence ratio 1.34, 95% CI 1.04–1.74) compared with those who were uninsured (Table 3). Compared with U.S.-born Latina women, the prevalence of contraindications was higher among Black women (prevalence ratio 1.37, 95% CI 1.14–1.64) and was lower among foreign-born Latina women (prevalence ratio 0.71, 95% CI 0.59–0.86). The prevalence of contraindications was lower among participants who attended a postpartum visit than those who did not (prevalence ratio 0.79, 95% CI 0.65–0.98).

Table 3.:
Characteristics Associated With Any Contraindication to Hormonal Contraception Among Postpartum Study Participants (n=1,444)

Of the 272 women with a contraindication to hormonal contraception, 28 (10.3%) were using combined hormonal contraception at the 6-month interview, and 115 (42.2%) were using a less effective method or no method (Table 4). Of the 75 women with a DMPA contraindication, six (8%) were using the method, and 30 (40%) were using a less effective method or no method. Among participants using combined hormonal contraception, 26 of 147 (17.7%) had a category 4, and 2 of 147 (1.4%) had a category 3 contraindication (not shown). Among the 24 participants with a combined hormonal contraception contraindication and were using pills, none had a contraindication to progestin-only pills, so it is possible that they were using progestin-only pills. Finally, none of the participants with a contraindication to progestin-only pills were using pills; one participant with an implant contraindication (category 3) was using the implant (not shown).

Table 4.:
Contraceptive Method Use at 6 Months After Delivery, by Contraindication Type


Using updated medical eligibility criteria in a sample of low-income, postpartum women, we found that one in five reported a contraindication to combined hormonal contraception, and the prevalence of contraindications to progestin-only methods was considerably lower (1/20 for DMPA and less than 1/100 for progestin-only pills). Consistent with other studies,4,6–8 migraine with aura and hypertension were the most frequently reported contraindications.

The prevalence of contraindications to hormonal contraception in our study is lower than that reported in another study of low-income Latina women in Texas, which included a larger share of women older than age 30 years.4,8,9 Compared with other studies conducted among reproductive-aged U.S. women,5,7 the prevalence of contraindications in our sample is somewhat higher. However, those studies did not assess migraine with aura and lack information on other contraindications.

The proportion of postpartum women with a contraindication is concerning given increasing rates of maternal morbidity and mortality; Texas has among the highest rates in the United States.13,16 In addition to age and obesity, factors associated with having a contraindication,4,5,7,8 our multivariable analysis demonstrated that the prevalence of contraindications was higher among Black women, who already have the highest rates of adverse outcomes for mothers and infants.13,14,17 This underscores the importance of clinician screening for contraindications postpartum to ensure pregnancy-related or chronic conditions are well-managed.

In contrast to prior research that found either no association4 or a negative association5 between health insurance and contraindications, the prevalence of contraindications was higher among insured participants in our sample, perhaps because access to health care resulted in diagnosis of medical conditions associated with contraindications or because participants with medical conditions paid out-of-pocket for insurance. Contraindications were more common among participants who did not have a postpartum visit. Although the reason for this is unclear, this is a missed opportunity to address health needs of those most at risk for adverse outcomes. Further research is needed to validate and further explore this association. Moreover, expanded eligibility criteria for Medicaid,15 by income and immigration status is needed to support maternal health.

Few women were using a contraindicated contraceptive method, and a large proportion were relying on less effective methods. Prior research from Texas suggests many of these women prefer to be using more effective contraception.11,12 In addition to cost barriers, some women report that clinicians discouraged or refused to provide their preferred method due to misclassification of contraindications, such as use of progestin-only methods while breastfeeding.18 Efforts are needed to educate clinicians about contraindications to ensure evidence-based provision of contraception.19

Clinicians should counsel on contraindications during prenatal care because many contraindications are diagnosed before or during pregnancy. Having multiple discussions about contraception over a longer period can allow patients to make a more informed decision about contraception after delivery. This may be particularly important for Black patients, immigrants, and other people of color who may experience pressure from clinicians to use contraception20 and report poorer quality of counseling.20–22

Prenatal contraceptive counseling is also important because low-income patients who lose health insurance before their postpartum visit18 may choose to begin contraception immediately after delivery if they are aware of contraindications before delivery. But people should not have to modify their preferred timing of contraceptive initiation due to health insurance limitations. Health care coverage that includes the full range of methods can ensure people can access their preferred method when they want to start it. Future research could assess whether patients were informed about contraindications prenatally and how counseling and contraindications informed their method preference, particularly in contexts of constrained contraceptive access.

We assessed contraindications by self-report. Although there is high concordance between self-report and clinician-identified contraindications,8,23 we had limited details on the type, timing, and severity of certain conditions. By considering these conditions as category 4, we may have underestimated category 3 relative to category 4. Additionally, we were unable to capture contraindications to IUDs or differentiate between combined hormonal or progestin-only pills. Given 19% of people using oral contraceptives within 1 year of delivery use progestin-only pills, the proportion of women using contraindicated combined hormonal contraception is likely inflated.24 Finally, our sample is not generalizable to all people after delivery, and additional research is needed to assess the prevalence of contraindications among other populations.

Clinicians who are caring for similar populations should be aware that one in five postpartum patients may have a contraindication and that the prevalence may be higher among patients already at higher risk for adverse birth outcomes. Thus, clinicians should screen for contraindications during prenatal and postpartum visits.


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