Secondary Logo

Maternal Immunization

Munoz, Flor M., MD, MSc; Jamieson, Denise J., MD, MPH

doi: 10.1097/AOG.0000000000003161
Contents: Prenatal Care: Clinical Expert Series
Take CME Test

Vaccines administered to women during pregnancy can provide protection against serious infectious diseases for the mother, for the newborn, or both. Maternal immunization boosts the concentration of maternal antibodies that can be transferred across the placenta to directly protect infants too young to be immunized. In addition, indirect protection through prevention of maternal infection and through breast milk antibodies can be achieved through maternal immunization. In general, inactivated vaccines are considered safe for pregnant women and their fetuses, whereas live vaccines are avoided owing to the theoretical potential risk to the fetus. However, the risks and benefits of vaccination must be carefully weighed and whenever possible, protection to the mother and her infant should be prioritized. Influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines are routinely recommended for all pregnant women in the United States. Seasonal inactivated influenza vaccine is recommended for all pregnant women in any trimester of pregnancy, mainly to protect the mother, but there is growing evidence that infants benefit from passive antibody protection against influenza complications. The Tdap vaccine is recommended during the third trimester of each pregnancy to provide optimal protection to infants who are at particularly high risk of pertussis complications and mortality in the first 3 months of life. The effects of maternal immunization on the prevention of maternal and infant disease have been demonstrated in observational and prospective studies of influenza and pertussis disease in the United States and worldwide. Maternal immunization has the potential to improve the health of mothers and young infants and therefore, other diseases of relevance during this period are now targets of active research and vaccine development, including group B streptococcus and respiratory syncytial virus. Similarly, several vaccines can be administered during pregnancy in special circumstances, when maternal health, travel, or other special situations arise. This article reviews the current recommendations for vaccination of women during pregnancy.

Obstetrician–gynecologists play a key role in maternal immunization, a critical public health strategy that may substantially reduce preventable diseases in mothers and infants.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas; and the Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.

Corresponding author: Denise Jamieson, MD, MPH, Department of Gynecology and Obstetrics, Emory University School of Medicine, 69 Jesse Hill Jr. Drive, Atlanta, GA 30303; email:

Financial Disclosure Dr. Munoz receives funds (paid to her institution) to conduct research on topics related to maternal immunization from the National Institutes of Health, the CDC, the Bill and Melinda Gates Foundation, the National Vaccine Program Office, and industry (Novavax, Inc). The other author did not report any potential conflicts of interest.

Peer reviews and author correspondence are available at

Received June 01, 2018

Received in revised form August 11, 2018

Accepted August 23, 2018

Obstetrician–gynecologists (ob-gyns) and other obstetric providers have been recommending specific vaccines in pregnancy for many years. For example, the Surgeon General first recommended that pregnant women receive influenza vaccines in the 1960s.1 However, the field of obstetrics and gynecology did not fully embrace maternal immunization as a priority until the 2009 influenza pandemic. From 2005 to 2008, the American College of Obstetricians and Gynecologists (ACOG) formed a small work group that focused on strengthening the role of ob-gyns as vaccinators. After the influenza pandemic in 2010, this group was reinvigorated, expanded, and renamed the Immunization Expert Work Group ( Recently, after the introduction and rapid spread of Zika in the Americas,2 the scope of this work was again expanded to include the infectious diseases that are not currently vaccine-preventable, and the group was renamed the “Immunization, Infectious Disease and Public Health Preparedness Expert Work Group.” The efforts of this group are largely focused on reducing morbidity and mortality from vaccine-preventable diseases and supporting and promoting the role of ob-gyns as immunizers. As part of these efforts, ACOG maintains a website ( that serves as a valuable resource for up-to-date immunization information relevant to practicing ob-gyns.

In developing immunization recommendations and resources, ACOG works in close collaboration with the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention (CDC). The Advisory Committee on Immunization Practices, which was established under Section 222 of the Public Health Service Act in 1964, provides advice and guidance about vaccine-preventable diseases to the director of the CDC. The Advisory Committee on Immunization Practices formulates and provides draft recommendations for the use of vaccines in the United States. Once approved, the recommendations are published as official recommendations in the Morbidity and Mortality Weekly report (MMWR) ( The recommendations of ACOG and the Advisory Committee on Immunization Practices are summarized in Table 1.

Table 1-a

Table 1-a

Table 1-b

Table 1-b

Back to Top | Article Outline


Vaccines given during pregnancy can provide maternal protection and protection for the newborn. In general, pregnant women are capable of developing an adequate immune response after vaccination, and although some, but not all, studies have shown a reduction in immunogenicity of vaccines administered to pregnant women compared with nonpregnant women, a clinically relevant reduction in vaccine effectiveness has not been demonstrated.3,4 Because neonates are susceptible to infections at birth and achieving adequate immunity requires repeated doses of childhood vaccines in the first few months of life, maternal vaccination is a feasible option to close this “immunity gap.”4 Maternal antibodies transferred across the placenta can protect infants too young to be immunized.

According to the Advisory Committee on Immunization Practices, inactivated vaccines can be administered safely during pregnancy, but pregnant women generally should not receive live vaccines owing to the potential, theoretical risk of infection to the fetus. In addition, women should avoid conception for 4 weeks after vaccination with a live vaccine. However, smallpox vaccine is the only vaccine with documented fetal infection resulting from vaccination during pregnancy. No cases of congenital rubella have been documented after inadvertent vaccination with measles–mumps–rubella (MMR) during pregnancy, and no adverse effects in the fetus have occurred after administration of yellow fever vaccine to pregnant women in the context of outbreaks. No evidence exists of risk to the fetus from vaccinating pregnant women with inactivated vaccines ( However, as with all clinical decisions in obstetrics, the risks and benefits of vaccination must be carefully weighed and there are sometimes substantial risks of avoiding vaccination. For example, although there is some evidence that pregnant women may be at increased risk for severe illness and death when infected with Ebola virus,5 most if not all Ebola vaccine trials have excluded pregnant women.6 An ongoing outbreak of Ebola in the Democratic Republic of the Congo7 highlights the urgent need for vaccines that can be used safely in pregnancy.

The safety of certain adjuvants in pregnancy has also been an area of concern. Adjuvants are substances added to vaccines to boost the immune response. Although influenza vaccines currently licensed and used in the United States do not contain adjuvants, in the event of a future influenza pandemic, adjuvants may be used to provide longer-lasting and broader protection and could allow for use of lower doses of antigen during a public health crisis when demand may outstrip vaccine supply.8 This was the case during the 2009 influenza pandemic, where pandemic vaccines containing adjuvants such as MF59 (an oil in water emulsion), were used for vaccination of pregnant women, mostly outside of the United States, without any associated adverse events.9–11 Additional safety data on adjuvanted vaccines used in pregnancy are needed.

Monitoring vaccine safety in pregnant women is a priority in the United States. Several large systems have been developed to monitor postlicensure vaccine safety. The Vaccine Adverse Event Reporting System is a passive reporting system administered by the U.S. Food and Drug Administration (FDA) and the CDC. After the approval of a vaccine, the FDA and CDC continue to monitor its safety by collecting information on adverse events among vaccinated persons through reports from health care providers and patients.12 The Vaccine Safety Datalink is a collaborative project between the CDC and eight large managed care organizations, which includes approximately 3% of the US population.13 Both the Vaccine Adverse Event Reporting System and Vaccine Safety Datalink were set up in 1990 after the National Childhood Vaccine Injury Act of 1986. Unlike the Vaccine Adverse Event Reporting System and Vaccine Safety Datalink, which collect information on adverse events among the broad U.S. population, the Vaccines and Medications in Pregnancy Surveillance System is specifically designed to assess the safety of vaccines and medications administered in pregnancy. Pregnancy-specific monitoring for adverse events is critically important because pregnant women are often excluded from clinical trials.14 The Vaccines and Medications in Pregnancy Surveillance System incorporates a prospective surveillance component in which pregnant women are prospectively enrolled in the first trimester. In addition, the Vaccines and Medications in Pregnancy Surveillance System incorporates a case–control surveillance component whereby mothers with infants with birth defects and two control groups of mothers are interviewed about vaccine exposure during pregnancy.15 The Clinical Immunization Safety Assessment is a network of vaccine safety experts from the CDC, seven medical research centers and other partners. Established in 2001, Clinical Immunization Safety Assessment conducts a variety of studies to identify adverse events after vaccination.16 In addition to these, vaccine registries are established by vaccine manufacturers to monitor adverse events after a vaccine is introduced, including reporting of pregnancies.

Back to Top | Article Outline


Although ACOG and the Advisory Committee on Immunization Practices have recommended the seasonal influenza vaccine in any trimester of pregnancy since 2004, vaccination rates among pregnant women remained low for many years at less than 25%.17 After the 2009 H1N1 pandemic, influenza coverage rates increased to about 50%18,19 (Fig. 1). Recently however, there is some evidence that coverage rates may have decreased again; as of November 2017, approximately 36% of pregnant women reported being vaccinated ( Regardless of whether this represents a recent downturn in vaccination coverage rates, one half or more of pregnant women do not get vaccinated for influenza each year, so there is opportunity for improvement. Because the recommendation and offering of influenza vaccine by health care providers has been consistently shown to increase vaccine uptake,18 it is critical that ob-gyns encourage their pregnant patients to get vaccinated and that their practices provide the vaccine. Health care provider recommendation and offering the vaccine at the time of routine prenatal care visits are the most important factors pregnant women consider when deciding on receiving influenza vaccine every year.

In 2011, the Advisory Committee on Immunization Practices recommended that unvaccinated pregnant women be vaccinated with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) after 20 weeks of gestation.20 As a result of an increasing trend in the incidence of pertussis morbidity and mortality in infants too young to be vaccinated in the United States, this recommendation was revised in 2012 to recommend Tdap vaccine during the third trimester of each pregnancy.21 In 2012, less than 10% of pregnant women were vaccinated; by 2015 slightly more than one half of pregnant women received the Tdap vaccination in pregnancy.22 Although this represents an improvement in the Tdap vaccination coverage rates of pregnant women in recent years, similar to influenza vaccination rates, there is still substantial opportunity for improvement. The American College of Obstetricians and Gynecologists has developed materials describing how to better integrate influenza and Tdap immunizations into obstetrics practice including designating an immunization coordinator, using prompts in the electronic medical record, and instituting standing orders.23

Back to Top | Article Outline


Influenza Vaccination

Although there is no evidence that pregnant women are more susceptible to influenza infection, they are more likely to have a severe disease.3 Although influenza vaccine was first recommended by the United States Surgeon General in 1960 after recognizing the effect of pandemic and seasonal influenza in pregnancy,1 recommendations were inconsistently implemented and have evolved over time. For example, in the 1990s there was period of time in which vaccination was recommended only for pregnant women with other underlying medical conditions24 and only in the third trimester.25 In 2004, the Advisory Committee on Immunization Practices recommended that all pregnant women be vaccinated regardless of trimester.26 In 2005, the World Health Organization, endorsed the recommendations to administer influenza vaccine during pregnancy, and in 2012, after the pandemic, the Special Advisory Group of Experts advised the World Health Organization to make influenza vaccination a priority worldwide. Since then, more than 30 countries have implemented maternal influenza immunization programs in Latin America, Africa, Asia, and Eastern Europe. Influenza vaccination is considered an essential element of prenatal care in the United States, according to ACOG.

Although the influenza vaccine is primarily given for maternal benefit, there is good evidence of infant benefit as well. Four large randomized, controlled clinical trials conducted outside of the United States (Bangladesh, South Africa, Mali, and Nepal) have demonstrated that influenza vaccination during pregnancy provides protection for women against influenza-like illness (reported vaccine efficacy of 19% [95% CI 1–34%] to 36% [95% CI 3.7–57.2%]), and laboratory-confirmed influenza (reported vaccine efficacy of 50% [95% CI 14.5–71.2%] to 70% [95% CI 42.2–85.8%]); and protection of infants in the first months of life against laboratory-confirmed influenza (reported vaccine efficacy from 30% to 62.8%).27–30 Because infants are not eligible for vaccination until 6 months of age, maternal vaccine can provide protection for the infant by active transfer of anti-influenza antibodies across the placenta.27,31 Several studies have shown that vaccination of pregnant women can also prevent influenza-related hospitalization in their infants.31–37 Furthermore, a recently published pooled analysis of three randomized clinical trials suggests that maternal influenza vaccination may reduce severe pneumonia in infants too young to be vaccinated.38 However, it is important to note that the protection from maternally derived antibodies is limited by the natural decay of immunoglobulins; this passive immunity for the infant wanes over time and may decline substantially before the infant can be vaccinated at 6 months of age.29,39

Various influenza vaccine formulations available in the United States can be administered to pregnant women, including egg- and cell-based inactivated trivalent or quadrivalent influenza vaccines, and more recently, recombinant vaccines. However, the live attenuated influenza vaccine is contraindicated during pregnancy.40 A recent case-control study raised some questions about the safety of influenza vaccine in the first trimester. Among women who had been previously vaccinated with a pH1N1-containing vaccine, vaccination during pregnancy was associated with an increased risk of spontaneous abortion.41 However, there were multiple methodologic issues with this study and a large body of evidence supports the safety of influenza vaccination in pregnancy, including the first trimester.42 Nonetheless, additional safety data, particularly in the first trimester, are needed.

Back to Top | Article Outline

Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine

Tetanus and diphtheria disease have been well controlled in the United States for many decades through high coverage rates of routine childhood immunization. Pertussis cases declined dramatically in the decades after the introduction of the whole cell pertussis and tetanus, diphtheria toxoid vaccines in the 1940s. However, during the 1980s, reports of pertussis disease began increasing to nearly 50,000 cases in 2012, the largest number of cases reported since the mid-1950s ( Pertussis is an acute respiratory infection caused by Bordetella pertussis that can be particularly severe and fatal in young infants. Although infants receive the pertussis vaccination, they are not well protected against the pertussis disease until they complete their primary series of vaccines at about 6 months of age.43 Infants who are unvaccinated or too young to be vaccinated (under 2 months of age), are at increased risk of pertussis and of severe disease because they also have little passive protection from maternally derived antibodies, given that women of childbearing age have little residual protection from their own childhood immunizations.44

The Tdap vaccine was licensed in the United States for adolescents and adults in 2005. In 2006, the Advisory Committee on Immunization Practices recommended that Tdap be given to women before becoming pregnant and that those not previously vaccinated should receive Tdap postpartum.45,46 Furthermore, the Advisory Committee on Immunization Practices recommended “cocooning” as a strategy to protect susceptible infants by vaccinating postpartum women and all those who would be in close contact with the neonate.46 However, it rapidly became apparent that this strategy was ineffective for a variety of reasons and the number of pertussis cases in the United States continued to rise.43,47 The Tdap vaccine was first recommended for pregnant women in the second or third trimester of gestation who had not previously been vaccinated with Tdap in 2011.20 After the accumulation of data that pertussis antibodies wane after a year, and taking into consideration the increasing burden of pertussis in infants in the United States, the Advisory Committee on Immunization Practices revised their recommendations in 2012 and since, the Advisory Committee on Immunization Practices recommends the Tdap vaccine be given to pregnant women during each pregnancy at 27–36 weeks of gestation.21 The rationale behind this recommendation is that every infant will benefit from a high concentration of maternally derived antibodies at birth and receive protection during the first few weeks of life, the period of greatest vulnerability.

The safety and effectiveness of maternal immunization with Tdap have been documented in the United States and in the United Kingdom, where the Tdap vaccination has also been recommended for pregnant women at 16–32 weeks of gestation since 2012. In a retrospective study, Winter et al48 evaluated a cohort of infants infected with pertussis from 2011 to 2015 in California, and compared the course of pertussis illness in infants whose mothers received Tdap during pregnancy with infants of unvaccinated mothers. Infants with pertussis born to mothers who received Tdap during pregnancy were significantly less likely to be hospitalized (43% vs 73%, relative risk [RR] 0.5 [95% CI 0.4–0.6]), or admitted to the intensive care unit (RR 0.8, 95% CI 0.7–0.9), when compared with infants of unvaccinated mothers. Furthermore, none of the infants born to mothers who received the Tdap vaccination required mechanical ventilation, developed seizures, or died, whereas these complications occurred in 8%, 4%, and 2%, respectively, of infants of unvaccinated mothers.

The most compelling evidence of the efficacy of maternal Tdap vaccination to prevent infant pertussis and its complications comes from data reported by the Public Health England program established in 2012.49,50 In the United Kingdom, where a 50–60% vaccine coverage has been achieved for Tdap during pregnancy, a marked decrease in infant hospitalizations associated with pertussis has been documented, and since the implementation of the program, the number of pertussis-associated deaths in infants has continued to decrease, with cases occurring almost exclusively in infants born to unvaccinated mothers. For the first time since the re-emergence of the pertussis epidemic, the incidence of pertussis in children younger than 3 months of age has decreased below that of older infants and adolescents in the United Kingdom. Furthermore, Tdap vaccination during pregnancy in the United States and the United Kingdom has not been associated with adverse events for the mother or the infant.51–55 In one retrospective, observational cohort study including more than 120,000 women in the United States, where safety was assessed through the identification of International Classification of Diseases, 9th Revision, Clinical Modification coded diagnoses, chorioamnionitis was diagnosed in 6.1% of vaccinated and 5.5% of unvaccinated women (adjusted RR 1.19; 95% CI 1.13–1.26), but the implication of this finding is unclear, as no biological plausibility exists, and the diagnosis of chorioamnionitis is often nonspecific.55 This finding has not been observed in other studies, or in population-based safety assessments of the Tdap vaccination program in the United Kingdom.

Important lessons have been learned from the Tdap vaccination programs in pregnant women, including the evaluation of the optimal timing of vaccination in pregnancy to achieve long-lasting protection in the newborn, and the assessment of potential effects of maternal antibodies on infant responses to active vaccination with pediatric tetanus, diphtheria and acellular or whole-cell pertussis vaccines (DTaP or DTP). Overall, it appears that vaccination in the second trimester or early third trimester of gestation results in higher antibody levels in infants at birth, and this finding was the basis for the widening of the window of vaccination down to 16 weeks of gestation in the United Kingdom.56,57 Regarding the effect of maternal antibodies on infant responses to active vaccination, it is clear that maternal antibodies do not interfere with the initial priming response of infants to DTaP or DTP vaccines, however, a blunting, or decreased geometric mean concentration of antibodies to various pertussis antigens (Pertussis toxin, filamentous hemagglutinin, and pertactin) or other vaccine antigens (Haemophilus influenzae type b or pneumococcal), have been reported in clinical trials of Tdap vaccines in pregnancy.58–60 Nonetheless, adequate boosting responses are documented in these infants, and the clinical implications of these findings is unknown. At this time, the benefit of preventing pertussis disease and mortality in infants in early life outweigh any potential risks of these observations.

Back to Top | Article Outline


Pneumococcal Vaccines

Pneumococcal conjugate and polysaccharide vaccines are recommended for adults at risk for pneumonia, including those who are immunocompromised, or who have chronic lung disease or other conditions that increase the risk for complications of respiratory infections, such as diabetes. Pregnant women with underlying medical conditions can receive pneumococcal vaccines when indicated.61,62

Back to Top | Article Outline

Meningococcal Vaccine

Meningococcal disease is a bacterial infection caused by Neisseria meningitidis and can present as meningitis, bacteremia, or pneumonia. N meningitidis colonizes the nasopharynx and is transmitted through respiratory tract secretions. The most important N meningitidis serotypes in the United States include serotypes B, C, Y, and W-135. There are several inactivated quadrivalent (serotypes A, C, W, Y), and monovalent (serotype B) meningococcal vaccines. MenACWY are protein-conjugated vaccines, and MenB are recombinant vaccines. The Advisory Committee on Immunization Practices recommends routine administration of MenACWY vaccine for all persons aged 11 through 18 years. MenB vaccines are recommended for adolescents and young adults at risk for meningococcal B infection. Risk factors for meningococcal infection include medical conditions such as complement component deficiencies (eg, C5-C9, properdin, factor H, factor D), use of complement-blocking drugs (such as eculizumab—SolirisR), functional or anatomic asplenia, including sickle cell disease, workplace-related risk, travel, or an outbreak situation. In 2013, the Advisory Committee on Immunization Practices stated that pregnancy should not preclude vaccination with meningococcal vaccines if indicated. Since that time, results from a randomized controlled trial of pregnant women in Mali was published. Pregnant women were given either influenza vaccine or MenACWY and there were no safety concerns noted. Therefore, use of MenACWY may be considered for pregnant women at risk for meningococcal disease.63,64 No studies have been conducted with MenB vaccines in pregnancy; therefore, the Advisory Committee on Immunization Practices suggests that serogroup B meningococcal vaccines should only be given to pregnant women or breastfeeding women who are at increased risk for serogroup B disease, when the benefits outweigh the risks.

Back to Top | Article Outline

Hepatitis A Vaccine

Hepatitis A is primarily transmitted from person to person through fecal-oral transmission. Adults tend to present with more severe disease than children when infected with hepatitis. Highly effective inactivated hepatitis A vaccines were first licensed by the FDA in 1995. In 2006, routine vaccination was recommended for all children 1 year of age or older in the United States. As such, children receive two doses of hepatitis vaccine before their second birthday, and benefit from lifelong protection. Although the safety of the hepatitis A vaccine in pregnancy has not been formally evaluated, because the hepatitis A vaccine is an inactivated viral vaccine, the theoretical risk in pregnancy is low. In susceptible pregnant women at high risk for hepatitis, the benefits of vaccination may outweigh the theoretical risks.65

Back to Top | Article Outline

Hepatitis B Vaccine

Hepatitis B virus is transmitted by parenteral and sexual contact, and serum, semen, and saliva are infectious. Routine screening of all pregnant women for HBsAg is recommended. HBsAg is on the surface of the virus and circulates freely in the serum in infected individuals. Without intervention, mother-to-child transmission of hepatitis B occurs in 5–90% of infants born to mothers with HBsAg and is largely dependent on the maternal viral load. Maternal antiviral therapy for pregnant women with high viral loads (ie, more than 200,000 international units/mL) is now more routinely recommended. In addition, immunoprophylaxis at birth is highly effective (great than 95%) in preventing vertical transmission of hepatitis and therefore, hepatitis B vaccine and hepatitis immunoglobulin within 12 hours is recommended for all infants born to mothers with hepatitis B.66

The hepatitis B vaccine is a recombinant inactivated viral vaccine. Susceptible pregnant women who are at risk for hepatitis B virus infection should be vaccinated for hepatitis B. Risk factors for infection include having more than one sexual partner during the previous 6 months, been evaluated or treated for a sexually transmitted infection, recent or current infection drug use, or having had an HBsAg-positive sexual partner. In November 2017, a single-antigen hepatitis vaccine with a novel adjuvant (HepB-CpG) was approved by the FDA for prevention of hepatitis B and in February 2018, the Advisory Committee on Immunization Practices recommended the HepB-CpG for persons aged 18 years or older. However, because there is insufficient information about the safety of HepB-CpG vaccine in pregnant women, it should not be used in pregnancy. An alternative hepatitis B vaccine should be used, when indicated, in pregnancy.67

Back to Top | Article Outline


Polio Vaccine

Poliovirus, an enterovirus, can cause poliomyelitis, a highly contagious infectious disease. Although most polio virus infections are asymptomatic, symptomatic infections are typically characterized by a nonspecific febrile illness that can progress to paralysis. Pregnancy is a risk factor for paralytic disease.

Inactivated poliovirus vaccine became available in the 1950s followed by oral poliovirus vaccine in the 1960s. Although there are sporadic cases of polio infection caused by vaccination with live oral polio vaccine, the last case of indigenously acquired case of polio caused by wild poliovirus was in 1979. To decrease the risk of polio infection after vaccination, in 2000, the Advisory Committee on Immunization Practices recommended that only inactivated polio vaccine be used for routine immunization. Although children in the United States are routinely immunized, there is generally no need for routine vaccination of adults living in the United States. However, vaccination is recommended for adults at increased risk such as those traveling to polio-endemic countries or laboratory workers handling poliovirus. Although no adverse effects of inactivated polio vaccine have been documented in pregnancy, vaccination should generally be avoided. However, if a pregnant woman is at risk for infection, vaccination can be considered.68

Back to Top | Article Outline

Yellow Fever Vaccine

Yellow fever is a mosquito-borne flavivirus present in tropical areas of sub-Saharan Africa and South America. The severity of disease can vary widely, resulting in asymptomatic infection or result in severe hemorrhagic disease with a high case-fatality rate. Yellow fever vaccine, which is a live vaccine, is recommended for those traveling to or living in an area with risk for yellow fever. Some countries require proof of vaccination for entry. However, waivers may be issued if a vaccination is contraindicated and pregnancy may be considered such a condition.69

Although the data are limited, pregnant women do not appear to be at increased risk for acquiring yellow fever nor at increased risk for severe disease compared with nonpregnant persons. From reports of large yellow fever outbreaks involving thousands of cases, vertical transmission has not been reported. Fetal infection resulting from maternal vaccination with live attenuated vaccine has also not been generally reported. During a large epidemic in Trinidad, approximately 100–200 pregnant women were likely inadvertently vaccinated. A retrospective study of 41 of these infants born to vaccinated mothers identified only one infant who had the yellow fever immunoglobulin M antibody. Because immunoglobulin M does not generally cross the placenta, this suggests that fetal exposure through vertical transmission may have occurred in this otherwise healthy infant.70 In terms of safety of the vaccine in pregnancy, several small, underpowered studies did not identify an increased risk of adverse pregnancy outcomes, including congenital malformations, preterm birth, stillbirth, and spontaneous abortion.71–73 In a case-control study of 39 women who had a spontaneous abortion and 74 pregnant women, the odds of being vaccinated during pregnancy were increased, but not statistically significant among the cases (2.3; 95% CI 0.65–8.03).71

Based on limited data, pregnant women should avoid vaccination with live yellow fever vaccine. However, if they are at substantial risk for yellow fever infection, the benefits and risks of infection should be weighed; vaccination may be a reasonable approach.69

Back to Top | Article Outline

Japanese Encephalitis Vaccine

Japanese encephalitis virus is a mosquito-borne flavivirus that occurs throughout Asia and parts of the western Pacific. Although the number of cases of Japanese encephalitis has decreased markedly over the past 30 years, U.S. travelers can still be at risk depending on where they travel, how long they stay, what season it is, and what type of activity they participate in. For example, travel outside an urban area, travel to areas with an ongoing outbreak, and staying in an endemic area more than one month all increase the risk of Japanese encephalitis. There are two licensed inactivated vaccines available in the United States. An inactivated mouse-brain derived vaccine has been available since 1992 and is licensed for persons aged older than 1 year. Supplies of this vaccine are limited because it is no longer manufactured and is therefore reserved for use in children. A new inactivated vaccine derived from Vero cell culture was licensed in 2009 for use in persons aged 17 years or older. Owing to limited safety data and a theoretical risk to the fetus, pregnant women should not routinely be immunized. However, for pregnant women at substantial risk for Japanese encephalitis, the benefits of vaccination for Japanese encephalitis may outweigh the risks.74

Back to Top | Article Outline

Rabies Vaccine

Rabies is a zoonotic disease caused by Rhabdoviridae lyssavirus. It is transmitted through the bite of an infected animal and disease in humans is almost always fatal. Owing to improved domestic animal vaccination and canine control programs, there has been a dramatic decline in rabies cases due to domestic animals. The few cases of rabies in the United States are mostly from wild animals, most commonly from bats. Postexposure prophylaxis, which includes wound cleansing, passive immunization with rabies immunoglobulin, and vaccination with inactivated rabies vaccine, is recommended in cases where a person is at relatively high risk for acquiring rabies. Because determining risk is relatively complex and must be individualized, the decision should be made in consultation with local, state, or federal public health officials.

Preexposure prophylaxis with inactivated rabies vaccine is recommended for persons in high-risk groups such as veterinarians and certain international travelers. If international travelers will be in contact with animals in areas where rabies is endemic, particularly if access to medical care, including rabies vaccination will be delayed, preexposure vaccination is recommended. Although safety data in pregnancy are limited, pregnant women at high risk for rabies infection should be promptly vaccinated.75

Back to Top | Article Outline

Anthrax Vaccination

Concern about the potential for anthrax to be used as a bioterror agent was heightened after the 2001 event involving Bacillus anthracis spores being disseminated through the U.S. postal system. Because the threat of B anthracis to national security remains, it is critical that response plans be in place for how to respond to another event involving B anthracis, including how pregnant women would be managed. Although there is no evidence that pregnant women are more susceptible to anthrax nor more likely to develop severe disease when compared with nonpregnant individuals, there is evidence that anthrax infection in pregnancy can be severe and can result in maternal and fetal death.76

From 1998 to 2004, the Department of Defense routinely vaccinated all nonpregnant military personnel for anthrax. Even though pregnant women were exempt from vaccination, more than 3,400 infants were born to women inadvertently vaccinated in the first trimester of pregnancy. Although not statistically significant, birth defects were slightly more common in infants born to mothers vaccinated in the first trimester when compared with infants born to women vaccinated outside of the first trimester (odds ratio 1.18; 95% CI 0.997–1.41).77

Based on a review of all available data including the Department of Defense data, the Advisory Committee on Immunization Practices recommends that pregnant women not be vaccinated in a preevent setting when the risk of anthrax exposure is low. However, in the setting of an anthrax event, pregnant women who are at risk for inhalational anthrax should be vaccinated.78

Back to Top | Article Outline

Smallpox Vaccine

The last smallpox outbreak in the United States was in 1949 and routine childhood vaccination was discontinued in 1971. Currently, vaccination is recommended only for specific populations at risk for occupational exposure such as some laboratory workers. However, there is concern that smallpox could be used as a bioterrorist weapon and preparedness plans include postevent vaccination for persons who are at high risk for smallpox infection during an intentional or accidental release of the smallpox virus.79 Plans specifically tailored for pregnant women must be included in these planning efforts.

Pregnant women infected with smallpox are more likely to have a severe disease, including the hemorrhagic form of smallpox and an increased risk of death compared with nonpregnant persons. The vaccine contains the smallpox vaccine, which is a live vaccine containing vaccinia, can rarely result in fetal infection. In a recent systematic review, 21 cases of fetal vaccinia were reported, dating as far back as 1809. Although there was no association between vaccination in pregnancy and adverse events such as spontaneous abortion, preterm birth or stillbirth, there was a small increased risk of congenital birth defects among women vaccinated in the first trimester.80 Overall, given the devastating effects of smallpox infection, the CDC recommends that pregnant women exposed to smallpox or at high risk for smallpox infection should be vaccinated.79

Back to Top | Article Outline


Measles–Mumps–Rubella and Varicella Vaccines

Live vaccines, including MMR and varicella vaccines, are contraindicated during pregnancy. However, these infections can be serious in pregnant women, and may be transmitted to the newborn infant. Therefore, women who are seronegative, or known to be unvaccinated, should be immunized with MMR and varicella vaccines in the postpartum period, or before becoming pregnant.81,82

Back to Top | Article Outline


Respiratory Syncytial Virus Vaccine

Respiratory syncytial virus (RSV) is a leading cause of morbidity and mortality among young infants.83 Although the search for a safe and effective RSV vaccine for children has been ongoing since the 1960s, challenges with the development of sufficiently immunogenic infant vaccines, safety concerns associated with previous candidate vaccines, and the need to protect infants in early life, maternal immunization strategies have been actively explored in the past 2 decades.84 For example, a small clinical trial evaluated the safety and immunogenicity of a purified fusion protein-2 RSV vaccine with adjuvant administered to 35 pregnant women in the third trimester. Although no safety concerns were raised, the vaccine failed to induce a robust antibody response.85 Since then, multiple RSV vaccine candidates are in various phases of development.84 A nanoparticle vaccine based on the fusion protein of RSV was safe and well tolerated, eliciting a significant immune response in the mothers and efficient antibody transfer to the infants, in phase II clinical trials. This promising vaccine candidate is currently being evaluated in a global phase III randomized, placebo-controlled clinical trial seeking to enroll approximately 8,000 pregnant women and their infants to demonstrate efficacy in the protection of severe lower respiratory tract RSV disease in infants in the first 6 months of life. Other RSV vaccine candidates based on the fusion protein, gene-vectors, and live attenuated formulations are also in active development and expected to enter clinical trials in target populations that include pregnant women, children, and the elderly. It is likely that to effectively prevent RSV disease in infants and young children, a combined approach that uses maternal immunization followed by vaccination of infants in the first year of life would be most effective. Given that infants who are born prematurely would not benefit from transplacentally transferred antibodies after maternal immunization, administration of passive antibodies for protection against RSV in early life remains a necessary strategy for preterm infants at risk.

Other important outcomes from studies of RSV vaccines in pregnancy include an evaluation of the effect of RSV in pregnancy and potential for protection of the mother. A few observational studies have shown that RSV can cause acute upper and lower respiratory tract disease in pregnant women, particularly in the third trimester of gestation.86–88 In a small case series, two of three pregnant women with confirmed RSV lower respiratory tract disease required mechanical ventilation and delivered early, at 34 weeks of gestation, owing to the severity of their RSV illness.86 In an observational study recently conducted in Houston, Texas, among 155 pregnant women followed during the winter respiratory viral season, one third (36%) developed acute lower respiratory tract illness, with a viral etiology identified in most, and RSV accounted for 10% of the cases. Only one woman was hospitalized, but women with lower respiratory tract illness often reported substantial morbidity including symptoms of wheezing, shortness of breath, chest pain, and use of prescription medications, suggesting that morbidity from RSV and other viral infections in pregnancy is substantial.89

Back to Top | Article Outline

Group B Streptococcus Vaccine

Group B streptococcus (GBS) is a common cause of neonatal sepsis in the United States despite considerable efforts to prevent GBS disease. In 1996–1997, ACOG, the American Academy of Pediatrics, and CDC issued recommendations for the prevention of early-onset GBS disease through screening of high-risk populations and intrapartum antibiotic prophylaxis. In 2002, universal screening at 35–37 weeks of gestation for all pregnant women was recommended. After the implementation of these prevention efforts, early-onset disease incidence markedly declined. However, the incidence of late-onset disease (after the first week of life) was not substantially reduced.90 A GBS vaccine administered during pregnancy could have the potential to protect infants after the first week of life and potentially to decrease the need for extensive prenatal screening and intrapartum prophylaxis programs. Several promising vaccine candidates are being evaluated in clinical trials and have been found to be safe and immunogenic.91,92

Developing an effective strategy for the prevention of GBS disease in mothers and infants is currently a priority, and studies are being conducted to better understand the epidemiology of GBS and its effect worldwide. Obstetric outcomes and fetal and neonatal morbidity, including stillbirths and neonatal deaths, could be prevented with an effective GBS vaccine administered during pregnancy.93 The World Health Organization, along with global stakeholders, have therefore proposed priority research and development pathways, as well as preferred product characteristics for GBS vaccines, to facilitate and accelerate the licensure of a GBS vaccine, as well as policy recommendations for its wide-scale use and implementation.94 One important goal of this effort is to conduct a pivotal efficacy trial with a vaccine that includes the most relevant GBS serotypes and specific, measurable, priority endpoints, such as the prevention of stillbirth, neonatal deaths, and late-onset GBS disease and its complications. Studies of GBS vaccines in pregnancy have been successfully conducted with monovalent (serotype III) and trivalent (serotypes Ia, Ib, III) conjugate vaccines, demonstrating their safety and tolerability, as well as efficient transplacental antibody transfer to the infant, but it is clear that multivalent vaccines are necessary to better protect mothers and infants against GBS.92,95–98 Furthermore, many research questions remain, including understanding the effect of maternal immunization on GBS colonization and disease in women; vaccine efficacy, correlates of protection, duration of protection in infant; potential protection through breastmilk antibodies; and the effect of maternal comorbidities on vaccine efficacy, among others. As with RSV, there is a real potential for a GBS vaccine to be available for maternal immunization in the near future.

Back to Top | Article Outline


In 2011, the CDC published 10 noteworthy public health achievements in the United States over the first 10 years of the 21st century (2001–2010).99 Declines in vaccine-preventable disease largely due to childhood vaccination programs were highlighted as one of the 10 success stories. During the second decade of the 21st century (2011–2020), maternal immunization may represent the next major public health success story. During this decade, influenza vaccination coverage rates among pregnant women have increased substantially and Tdap was newly recommended and implemented for use and in pregnancy. There is tremendous potential for maternal immunization to further improve the health of mothers and their young infants and some exciting developments in the field of vaccine research and development. Other diseases of relevance during this period are now targets of active research and vaccine development, including RSV and GBS. Overall, maternal immunization as a public health strategy supported by antenatal care programs, is a platform that may be used to substantially reduce the effect of infectious diseases in mothers and infants.

Back to Top | Article Outline

CME FOR THE CLINICAL EXPERT SERIES Learning Objectives for “Maternal Immunization”

After completing this learning experience, the involved learner should be able to:

  • List common infectious diseases for which maternal immunization can provide passive immunization to the fetus and young infant;
  • Discuss diseases for which maternal immunization is recommended for the protection of the mother and newborn infant;
  • Know the potential risks of inadvertent immunization with a live vaccine during gestation; and
  • Implement a comprehensive plan to ensure appropriate immunizations are given during pregnancy in the health care provider's practice.
Back to Top | Article Outline

Instructions for Obtaining AMA PRA Category 1 Credits TM

Continuing Medical Education credit is provided through joint providership with The American College of Obstetricians and Gynecologists.

Obstetrics & Gynecology includes CME-certified content that is designed to meet the educational needs of its readers. This article is certified for 2 AMA PRA Category 1 Credits TM. This activity is available for credit through April 30, 2022.

Back to Top | Article Outline

Accreditation Statement

ACCME Accreditation

The American College of Obstetricians and Gynecologists is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Back to Top | Article Outline

AMA PRA Category 1 Credit(s) TM

The American College of Obstetricians and Gynecologists designates this journal-based CME activity for a maximum of 2 AMA PRA Category 1 Credits TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Back to Top | Article Outline

College Cognate Credit(s)

The American College of Obstetricians and Gynecologists designates this journal-based CME activity for a maximum of 2 Category 1 College Cognate Credits. The College has a reciprocity agreement with the AMA that allows AMA PRA Category 1 Credits TM to be equivalent to College Cognate Credits.

Back to Top | Article Outline

Disclosure of Faculty and Planning Committee Industry Relationships

In accordance with the College policy, all faculty and planning committee members have signed a conflict of interest statement in which they have disclosed any financial interests or other relationships with industry relative to article topics. Such disclosures allow the participant to evaluate better the objectivity of the information presented in the articles.

Back to Top | Article Outline

How to Earn CME Credit

To earn CME credit, you must read the article in Obstetrics & Gynecology and complete the quiz, answering at least 70 percent of the questions correctly. For more information on this CME educational offering, visit the Lippincott CMEConnection portal at to register and to complete the CME activity online. ACOG Fellows will receive 50% off by using coupon code, ONG50.

Hardware/software requirements are a desktop or laptop computer (Mac or PC) and an Internet browser. This activity is available for credit through April 30, 2022. To receive proper credits for this activity, each participant will need to make sure that the information on their profile for the CME platform (where this activity is located) is updated with 1) their date of birth (month and day only) and 2) their ACOG ID. In addition, participants should select that they are board-certified in obstetrics and gynecology.

The privacy policies for the Obstetrics & Gynecology website and the Lippincott CMEConnection portal are available at and, respectively.

Back to Top | Article Outline

Contact Information

Questions related to transcripts may be directed to For other queries, please contact the Obstetrics & Gynecology Editorial Office, 202-314-2317 or For queries related to the CME test online, please contact or 1-800-787-8985.

Back to Top | Article Outline


1. Burney LE. Influenza immunization. Public Health Rep 1960;75:944.
2. Petersen LR, Jamieson DJ, Powers AM, Honein MA. Zika virus. N Engl J Med 2016;374:1552–63.
3. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med 2014;370:2211–8.
4. Omer SB. Maternal immunization. N Engl J Med 2017;376:1256–67.
5. Jamieson DJ, Uyeki TM, Callaghan WM, Meaney-delman D, Rasmussen SA. What obstetrician–gynecologists should know about Ebola. Obstet Gynecol 2014;124:1005–10.
6. Haddad LB, Horton J, Ribner BS, Jamieson DJ. Ebola infection in pregnancy: a global perspective and lessons learned. Clin Obstet Gynecol 2018;61:186–96.
7. Kelly JD, Mukadi P, Dhillon RS. Beyond vaccines: improving survival rates in the DRC Ebola outbreak. Lancet 2018;391:2321.
8. Jamieson DJ, Rasmussen SA. The safety of adjuvants in influenza vaccines during pregnancy: what do we know and why do we need them? Am J Obstet Gynecol 2012;207:145–6.
9. Tsai T, Kyaw MH, Novicki D, Nacci P, Rai S, Clemens R. Exposure to MF59-adjuvanted influenza vaccines during pregnancy—a retrospective analysis. Vaccine 2010;28:1877–80.
10. Heikkinen T, Young J, van Beek E, Franke H, Verstraeten T, Weil JG, et al. Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study. Am J Obstet Gynecol 2012;207:177–8.
11. Fabiani M, Bella A, Rota MC, Clagnan E, Gallo T, D'Amato M, et al. A/H1N1 pandemic influenza vaccination: a retrospective evaluation of adverse maternal, fetal and neonatal outcomes in a cohort of pregnant women in Italy. Vaccine 2015;33:2240–7.
12. Shimabukuro TT, Nguyen M, Martin D, DeStefano F. Safety monitoring in the vaccine adverse event reporting system (VAERS). Vaccine 2015;33:4398–405.
13. Baggs J, Gee J, Lewis E, Fowler G, Benson P, Lieu T, et al. The vaccine safety datalink: a model for monitoring immunization safety. Pediatrics 2011;127(suppl 1):S45–53.
14. Blehar MC, Spong C, Grady C, Goldkind SF, Sahin L, Clayton JA. Enrolling pregnant women: issues in clinical research. Womens Health Issues 2013;23:e39–45.
15. Schatz M, Chambers CD, Jones KL, Louik C, Mitchell AA. Safety of influenza immunizations and treatment during pregnancy: the vaccines and medications in pregnancy surveillance system. Am J Obstet Gynecol 2011;204(6 suppl):S64–8.
16. LaRussa PS, Edwards KM, Dekker CL, Klein NP, Halsey NA, Marchant C, et al. Understanding the role of human variation in vaccine adverse events: the clinical immunization safety assessment network. Pediatrics 2011;127(suppl 1):S65–73.
17. Ahluwalia IB, Jamieson DJ, Rasmussen SA, D'Angelo D, Goodman D, Kim H. Correlates of seasonal influenza vaccine coverage among pregnant women in Georgia and Rhode Island. Obstet Gynecol 2010;116:949–55.
18. Ding H, Black CL, Ball S, Fink RV, Williams WW, Fiebelkorn AP, et al. Influenza vaccination coverage among pregnant women—United States, 2016–17 influenza season. MMWR Morb Mortal Wkly Rep 2017;66:1016–22.
19. Ding H, Black CL, Ball S, Donahue S, Fink RV, Williams WW, et al. Influenza vaccination coverage among pregnant women—United States, 2014–15 influenza season. MMWR Morb Mortal Wkly Rep 2015;64:1000–5.
20. Centers for Disease Control and Prevention (CDC). Update recommendations for use of tettanus toxoid, reduced diphteria toxoid and acellular pertussis vaccine (TDap) in pregnant woman and persons who have or anticipate having close contact with and infant <12 months—advisory committee on immunization pr. MMWR Surveill Summ 2011;60:1424–6.
21. Centers for Disease Control and Prevention. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women—advisory committee on immunization practices (ACIP), 2012. MMWR Morb Mortal Wkly Rep 2013;62:131–5.
22. Kerr S, Van Bennekom CM, Liang JL, Mitchell AA. Tdap vaccination coverage during pregnancy—selected sites, United States, 2006–2015. MMWR Morb Mortal Wkly Rep 2017;66:1105–8.
23. Integrating immunizations into practice. Committee Opinion No. 661. American College of Obstetricians and Gynecologists. Obstet Gynecol 2016;127:e104–7.
24. Centers for Disease Control and Prevention. Prevention and control of influenza. Recommendations of the immunization practices advisory committee (ACIP). MMWR Morb Mortal Wkly Rep 1990;39:1–15.
25. Centers for Disease Control and Prevention. Prevention and control of influenza: recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep 1999;48:1–28.
26. Centers for Disease Control and Prevention. Prevention and control of influenza: recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep 2004;53:1–40.
27. Zaman K, Roy E, Arifeen SE, Rahman M, Raqib R, Wilson E, et al. Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med 2008;359:1555–64.
28. Madhi SA, Cutland CL, Kuwanda L, Weinberg A, Hugo A, Jones S, et al. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med 2014;371:918–31.
29. Tapia MD, Sow SO, Tamboura B, Tégueté I, Pasetti MF, Kodio M, et al. Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind, randomised phase 4 trial. Lancet Infect Dis 2016;16:1026–35.
30. Steinhoff MC, Katz J, Englund JA, Khatry SK, Shrestha L, Kuypers J, et al. Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial. Lancet Infect Dis 2017;17:981–9.
31. Poehling KA, Szilagyi PG, Staat MA, Snively BM, Payne DC, Bridges CB, et al. Impact of maternal immunization on influenza hospitalizations in infants. Am J Obstet Gynecol 2011;204(6 suppl):S141–8.
32. Black SB, Shinefield HR, France EK, Fireman BH, Platt ST, Shay D, et al. Effectiveness of influenza vaccine during pregnancy in preventing hospitalizations and outpatient visits for respiratory illness in pregnant women and their infants. Am J Perinatol 2004;21:333–9.
33. France EK, Smith-Ray R, McClure D, Hambidge S, Xu S, Yamasaki K, et al. Impact of maternal influenza vaccination during pregnancy on the incidence of acute respiratory illness visits among infants. Arch Pediatr Adolesc Med 2006;160:1277–83.
34. Benowitz I, Esposito DB, Gracey KD, Shapiro ED, Vázquez M. Influenza vaccine given to pregnant women reduces hospitalization due to influenza in their infants. Clin Infect Dis 2010;51:1355–61.
35. Eick AA, Uyeki TM, Klimov A, Hall H, Reid R, Santosham M, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med 2011;165:104–11.
36. Dabrera G, Zhao H, Andrews N, Begum F, Green H, Ellis J, et al. Effectiveness of seasonal influenza vaccination during pregnancy in preventing influenza infection in infants, England, 2013/14. Euro Surveill 2014;19:20959.
37. Regan AK, de Klerk N, Moore HC, Omer SB, Shellam G, Effler PV. Effect of maternal influenza vaccination on hospitalization for respiratory infections in newborns: a retrospective cohort study. Pediatr Infect Dis J 2016;35:1097–103.
38. Omer SB, Clark DR, Aqil AR, Tapia MD, Nunes MC, Kozuki N. Maternal influenza immunization and prevention of severe clinical pneumonia in young infants. Pediatr Infect Dis J 2018;37:436–40.
39. Nunes MC, Cutland CL, Jones S, Hugo A, Madimabe R, Simões EA. Duration of infant protection against influenza illness conferred by maternal immunization secondary analysis of a randomized clinical trial. JAMA Pediatr 2016;170:840–7.
40. Grohskopf L, Sokolow L, Broder K. Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices- United States, 2017-2017 influenza season. Morb Mortal Wkly Rep 2016;65:1–36.
41. Donahue JG, Kieke BA, King JP, DeStefano F, Mascola MA, Irving SA, et al. Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12. Vaccine 2017;35:5314–22.
42. Sperling RS, Riley LE; Immunization and Emerging Infections Expert Work Group. Influenza vaccination, pregnancy safety, and risk of early pregnancy loss. Obstet Gynecol 2018;131:799–802.
43. Gall SA. Prevention of pertussis, tetanus, and diphtheria among pregnant, postpartum women, and infants. Clin Obstet Gynecol 2012;55:498–509.
44. Healy CM, Munoz FM, Rench MA, Halasa NB, Edwards KM, Baker CJ. Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum. J Infect Dis 2004;190:335–40.
45. Broder KR, Cortese MM, Iskander JK, Kretsinger K, Slade BA, Brown KH, et al. Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006;55:1–34.
46. Kretsinger K, Broderv KR, Cortese MM, Joyce MP, Ortega-Sanchez I, Lee GM, et al. Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel. MMWR Recomm Rep 2006;55:1–37.
47. Healy CM, Rench MA, Wootton SH, Castagnini LA. Evaluation of the impact of a pertussis cocooning program on infant pertussis infection. Pediatr Infect Dis J 2015;34:22–6.
48. Winter K, Nickell S, Powell M, Harriman K. Effectiveness of prenatal versus postpartum tetanus, diphtheria, and acellular pertussis vaccination in preventing infant pertussis. Clin Infect Dis 2017;64:3–8.
49. Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet 2014;384:1521–8.
50. Dabrera G, Amirthalingam G, Andrews N, Campbell H, Ribeirov S, Kara E, et al. A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012-2013. Clin Infect Dis 2015;60:333–7.
51. Donegan K, King B, Bryan P. Safety of pertussis vaccination in pregnant women in UK: observational study. BMJ 2014;349:g4219.
52. Zheteyeva YA, Moro PL, Tepper NK, Rasmussen SA, Barash FE, Revzina NV, et al. Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women. Am J Obstet Gynecol 2012;207:59.e1–7.
53. Morgan JL, Baggari SR, McIntire DD, Sheffield JS. Pregnancy outcomes after antepartum tetanus, diphtheria, and acellular pertussis vaccination. Obstet Gynecol 2015;125:1433–8.
54. Shakib JH, Korgenski K, Sheng X, Varner MW, Pavia AT, Byington CL. Tetanus, diphtheria, acellular pertussis vaccine during pregnancy: pregnancy and infant health outcomes. J Pediatr 2013;163:1422–6.e1-4.
55. Kharbanda EO, Vazquez-Benitez G, Lipkind HS, Klein NP, Cheetham TC, Naleway A, et al. Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes. JAMA 2014;312:1897–904.
56. Eberhardt CS, Blanchard-Rohner G, Lemaître B, Boukrid M, Combescure C, Othenin-Girard V, et al. Maternal immunization earlier in pregnancy maximizes antibody transfer and expected infant seropositivity against pertussis. Clin Infect Dis 2016;62:829–36.
57. Abu Raya B, Srugo I, Kessel A, Peterman M, Bader D, Gonen R, et al. The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels—a prospective study. Vaccine 2014;32:5787–93.
58. Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA 2014;311:1760–9.
59. Maertens K, Caboré RN, Huygen K, Hens N, Van Damme P, Leuridan E. Pertussis vaccination during pregnancy in Belgium: results of a prospective controlled cohort study. Vaccine 2016;34:142–50.
60. Hoang HTT, Leuridan E, Maertens K, Nguyen TD, Hens N, Vu NH, et al. Pertussis vaccination during pregnancy in Vietnam: results of a randomized controlled trial Pertussis vaccination during pregnancy. Vaccine 2016;34:151–9.
61. Centers for Disease Control and Prevention (CDC). Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2012;61:816–9.
62. Centers for Disease Control and Prevention (CDC), Advisory Committee on Immunization Practices. Updated recommendations for prevention of invasive pneumococcal disease among adults using the 23-valent pneumococcal polysaccharide vaccine (PPSV23). MMWR Morb Mortal Wkly Rep 2010;59:1102–6.
63. Cohn AC, MacNeil JR, Clark TA, Ortega-Sanchez IR, Briere EZ, Meissner HC, et al. Prevention and control of meningococcal disease recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep2013;62:1–32.
64. Patton ME, Stephens D, Moore K, MacNeil JR. Updated recommendations for use of MenB-FHbp serogroup B meningococcal vaccine—advisory committee on immunization practices, 2016. MMWR Morb Mortal Wkly Rep 2017;66:509–13.
65. Centers for Disease Control and Prevention (CDC). Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006;55:1–23.
66. Nelson NP, Jamieson DJ, Murphy TV. Prevention of perinatal hepatitis B virus transmission. J Pediatr Infect Dis Soc 2014;3(suppl 1):7–12.
67. Schillie S, Harris A, Link-Gelles R, Romero J, Ward J, Nelson N. Recommendations of the advisory committee on immunization practices for use of a hepatitis B vaccine with a novel adjuvant. MMWR Morb Mortal Wkly Rep 2018;67:455–8.
68. Prevots DR, Burr RK, Sutter RW, Murphy TV; Advisory Committee on Immunization Practices. Poliomyelitis prevention in the United States. Updated recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep 2000;49:1–22.
69. Staples JE, Gershman M, Fischer M; Centers for Disease Control and Prevention (CDC). Yellow fever vaccine: recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep 2010;59:1–27.
70. Tsai TF, Paul R, Lynberg MC, Letson GW. Congenital yellow fever virus infection after immunization in pregnancy. J Infect Dis 1993;168:1520–3.
71. Nishioka SdeA, Nunes-Araújo FR, Pires WP, Silva FA, Costa HL. Yellow fever vaccination during pregnancy and spontaneous abortion: a case-control study. Trop Med Int Health 1998;3:29–33.
72. Cavalcanti DP, Salomão MA, Lopez-Camelo J, Pessoto MA. Early exposure to yellow fever vaccine during pregnancy. Trop Med Int Heal 2007;12:833–7.
73. Suzano CES, Amaral E, Sato HK, Papaiordanou PM; Campinas Group on Yellow Fever Immunization during Pregnancy. The effects of yellow fever immunization (17DD) inadvertently used in early pregnancy during a mass campaign in Brazil. Vaccine 2006;24:1421–6.
74. Fischer M, Lindsey N, Staples JE, Hills S; Centers for Disease Control and Prevention (CDC). Japanese encephalitis vaccines: recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep 2010;59:1–27.
75. Manning SE, Rupprecht CE, Fishbein D, Hanlon CA, Lumlertdacha B, Guerra M, et al. Human rabies prevention—United States, 2008—recommendations of the Advisory Committee on Immunization Practices. Morb Mortal Wkly Rep 2008;57:15–28.
76. Meaney-Delman D, Zotti ME, Rasmussen SA, Strasser S, Shadomy S, Turcios-Ruiz RM, et al. Anthrax cases in pregnant and postpartum women: a systematic review. Obstet Gynecol 2012;120:1439–49.
77. Ryan MAK, Smith TC, Sevick CJ, Honner WK, Loach RA, Moore CA, et al. Birth defects among infants born to women who received anthrax vaccine in pregnancy. Am J Epidemiol 2008;168:434–42.
78. Meaney-Delman D, Zotti ME, Creanga AA, Misegades LK, Wako E, Treadwell TA, et al. Special considerations for prophylaxis for and treatment of anthrax in pregnant and postpartum women. Emerg Infect Dis 2014;20:1–6.
79. Petersen BW, Damon IK, Pertowski CA, Meaney-Delman D, Guarnizo JT, Beigi RH, et al. Clinical guidance for smallpox vaccine use in a postevent vaccination program. MMWR Recomm Rep 2015;64:1–26.
80. Badell ML, Meaney-Delman D, Tuuli MG, Rasmussen SA, Petersen BW, Sheffield JS, et al. Risks associated with smallpox vaccination in pregnancy: a systematic review and meta-analysis. Obstet Gynecol 2015;125:1439–51.
81. Control and prevention of rubella: evaluation and management of suspected outbreaks, rubella in pregnant women, and surveillance for congenital rubella syndrome. MMWR Recomm Rep 2001;50:1–23.
82. Marin M, Güris D, Chaves SS, Schmid S, Seward JF. Advisory Committee on Immunization Practices C for DC and P (CDC). Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2007;56:1–40.
83. Polack FP. The changing landscape of respiratory syncytial virus. Vaccine 2015;33:6473–8.
84. Saso A, Kampmann B. Vaccination against respiratory syncytial virus in pregnancy: a suitable tool to combat global infant morbidity and mortality? Lancet Infect Dis 2016;16:e153–63.
85. Munoz FM, Piedra PA, Glezen WP. Safety and immunogenicity of respiratory syncytial virus purified fusion protein-2 vaccine in pregnant women. Vaccine 2003;21:3465–7.
86. Wheeler SM, Dotters-Katz S, Heine RP, Grotegut CA, Swamy GK. Maternal effects of respiratory syncytial virus infection during pregnancy. Emerg Infect Dis 2015;21:1951–5.
87. Chu HY, Katz J, Tielsch J, Khatry SK, Shrestha L, LeClerq SC, et al. Clinical presentation and birth outcomes associated with respiratory syncytial virus infection in pregnancy. PLoS One 2016;11:e0152015.
88. Chaw L, Kamigaki T, Burmaa A, Urtnasan C, Od I, Nyamaa G, et al. Burden of influenza and respiratory syncytial virus infection in pregnant women and infants under 6 months in Mongolia: a prospective cohort study. PLoS One 2016;11:e0148421.
89. Hause AM, Avadhanula V, Maccato ML, Pinell PM, Bond N, Santarcangelo P, et al. A cross-sectional surveillance study of the frequency and etiology of acute respiratory illness among pregnant women. J Infect Dis 2018;218:528–35.
90. Centers for Disease Control and Prevention. Prevention of perinatal group B streptococcal disease. MMWR Recomm Rep 2010;59:1–32.
91. Munoz FM, Ferrieri P. Group B Streptococcus vaccination in pregnancy: moving toward a global maternal immunization program. Vaccine 2013;31:D46–51.
92. Donders GG, Halperin SA, Devlieger R, Baker S, Forte P, Wittke F, et al. Maternal immunization with an investigational trivalent group B streptococcal vaccine. Obstet Gynecol 2016;127:213–21.
93. Seale AC, Bianchi-Jassir F, Russell NJ, Kohli-Lynch M, Tann CJ, Hall J, et al. Estimates of the burden of group B streptococcal disease worldwide for pregnant women, stillbirths, and children. Clin Infect Dis 2017;65(suppl 2):S200–19.
94. Vekemans J, Moorthy V, Friede M, Alderson MR, Sobanjo-Ter Meulen A, Baker C, et al. Maternal immunization against Group B streptococcus: World Health Organization research and development technological roadmap and preferred product characteristics. Vaccine 2018 [Epub ahead of print].
95. Madhi SA, Cutland CL, Jose L, Koen A, Govender N, Wittke F, et al. Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial. Lancet Infect Dis 2016;16:923–34.
96. Heyderman RS, Madhi SA, French N, Cutland C, Ngwira B, Kayambo D, et al. Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial. Lancet Infect Dis 2016;16:546–55.
97. Paoletti LC, Rench MA, Kasper DL, Molrine D, Ambrosino D, Baker CJ. Effects of alum adjuvant or a booster dose on immunogenicity during clinical trials of group B streptococcal type III conjugate vaccines. Infect Immun 2001;69:6696–701.
98. Baker CJ, Rench MA, McInnes P. Immunization of pregnant women with group B streptococcal type III capsular polysaccharide-tetanus toxoid conjugate vaccine. Vaccine 2003;21:3468–72.
99. Centers for Disease Control and Prevention (CDC). Ten great public health achievements—United States, 2001-2010. MMWR Morb Mortal Wkly Rep 2011;60:619–23.

Supplemental Digital Content

Back to Top | Article Outline
© 2019 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.