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Prediction of Treatment Outcomes After Global Endometrial Ablation

El-Nashar, Sherif A. MBBCh, MS; Hopkins, Matthew R. MD; Creedon, Douglas J. MD, PhD; St. Sauver, Jennifer L. PhD; Weaver, Amy L. MS; McGree, Michaela E. BS; Cliby, William A. MD; Famuyide, Abimbola O. MBBS

doi: 10.1097/AOG.0b013e31818f5a8d
Original Research

OBJECTIVE: To report rates of amenorrhea and treatment failure after global endometrial ablation and to estimate the association between patient factors and these outcomes by developing and validating prediction models.

METHODS: From January 1998 through December 2005, 816 women underwent global endometrial ablation with either a thermal balloon ablation or radio frequency ablation device; 455 were included in a population-derived cohort (for model development), and 361 were included in a referral-derived cohort (for model validation). Amenorrhea was defined as cessation of bleeding from immediately after ablation through at least 12 months after the procedure. Treatment failure was defined as hysterectomy or reablation for patients with bleeding or pain. Logistic and Cox proportional hazard regression models were used in model development and validation of potential predictors of outcomes.

RESULTS: The amenorrhea rate was 23% (95% confidence interval [CI] 19–28%) and the 5-year cumulative failure rate was 16% (95% CI 10–20%). Predictors of amenorrhea were age 45 years or older (adjusted odds ratio [aOR] 2.6, 95% CI 1.6–4.3); uterine length less than 9 cm (aOR 1.8, 95% CI 1.1–3.1); endometrial thickness less than 4 mm (aOR 2.7, 95% CI 1.2–6.3); and use of radio-frequency ablation instead of thermal balloon ablation (aOR 2.8, 95% CI 1.7–4.9). Predictors of treatment failure included age younger than 45 years (adjusted hazard ratio [aHR] 2.6, 95% CI 1.3–5.1); parity of 5 or greater (aHR 6.0, 95% CI 2.5–14.8); prior tubal ligation (aHR 2.2, 95% CI 1.2–4.0); and history of dysmenorrhea (aHR 3.7, 95% CI 1.6–8.5). After global endometrial ablation, 23 women (5.1%, 95% CI 3.2–7.5%) had pelvic pain, three (0.7%, 95% CI 0.1–1.9%) were pregnant, and none (95% CI 0–0.8%) had endometrial cancer.

CONCLUSION: Population-derived rates and predictors of treatment outcomes after global endometrial ablation may help physicians offer optimal preprocedural patient counseling.


Population-derived estimates and predictors of outcome after global endometrial ablation may improve preprocedural patient counseling.

From the Divisions of 1Gynecology, 2Epidemiology, 3Biostatistics, and 4Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota.

Editing, proofreading, and reference verification were provided by the Section of Scientific Publications, Mayo Clinic.

These data were presented at the Global Congress of Minimally Invasive Gynecology, 36th American Association of Gynecologic Laparoscopists Annual Meeting, Washington, DC, November 13–17, 2007.

Corresponding author: Abimbola O. Famuyide, MBBS, Division of Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; e-mail:

Financial Disclosure The authors did not report any potential conflicts of interest.

Excessive menstrual bleeding is a common problem that adversely affects women’s health and health resources worldwide.1 Endometrial ablation, a less invasive alternative to hysterectomy, aims to treat menorrhagia by selectively destroying the endometrium while preserving the uterus.2 Early endometrial ablation procedures were hysteroscopy dependent, required surgical dexterity, and were associated with clinically significant complications such as uterine perforation and fluid overload in 3% of patients.3,4 Recently, newer global endometrial ablation procedures have been introduced, and because of their ease of use and better safety profiles, they gradually have taken the place of older endometrial ablation procedures. To date, the U.S. Food and Drug Administration has approved five global endometrial ablation technologies: thermal balloon ablation, cryoablation, circulated hot fluid ablation, microwave ablation, and bipolar radio-frequency ablation.5

Compared with hysterectomy, global endometrial ablation initially showed similar efficacy with lower cost and complication rates; however, these favorable outcomes seemed to diminish with time, because 30% of patients required hysterectomy within 4 years after ablation.6 By identifying predictors of treatment outcomes after global endometrial ablation, patient counseling could improve and failure rates could decrease with better patient selection.7 Nevertheless, few studies have examined predictors of treatment failure,8,9 and these studies used inconsistent definitions of treatment failure and were not population derived. They also were limited by low statistical power (from relatively small sample sizes) and thus failed to identify valid independent predictors of treatment outcomes. The objectives of our study were to determine population-derived rates of amenorrhea and treatment failure after global endometrial ablation and to estimate the association between patient factors and these outcomes by developing and validating predicting models.

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This study was approved by the Mayo Clinic and Olmsted Medical Center institutional review boards. The manuscript was written in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology statement.10

Only women who gave consent to use their medical records in research were included in the analysis. The study established two independent patient cohorts. The model development cohort included women who underwent global endometrial ablation from January 1, 1998, through December 31, 2005, and resided in Olmsted County, Minnesota. Data from this population-derived cohort were used to develop prediction models for amenorrhea and treatment failure after global endometrial ablation. A model validation cohort was constructed from referred patients who underwent global endometrial ablation during the same period at Mayo Clinic but resided outside Olmsted County.

The model development cohort was constructed using data from the Rochester Epidemiology Project. The Rochester Epidemiology Project maintains a unique medical records linkage system that encompasses all health care delivered to residents of Olmsted County. Mayo Clinic and the Olmsted Medical Center provide primary care and comprehensive care in virtually every medical specialty, and more than 83% of the county’s population is examined at least once per year in one of these facilities.11 The Rochester Epidemiology Project medical records system was used to identify all women who underwent global endometrial ablation by searching for the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 68.23 for endometrial ablation.12 The model validation cohort was identified by the electronic medical records linkage system at Mayo Clinic by searching for the same ICD-9-CM code. Verification of the retrieved cases in both cohorts was conducted by chart review.

The main outcome measures were amenorrhea and treatment failure after global endometrial ablation. Amenorrhea was defined as cessation of bleeding from immediately after ablation through at least 12 months after the procedure. Treatment failure was defined as bleeding or pain after global endometrial ablation that required performance of hysterectomy or reablation. Time to treatment failure was measured for patients who underwent hysterectomy or reablation. For women who did not have this outcome, their duration of follow-up was censored at the time of their last contact or death before the end of the study period (December 31, 2006).

Reliability of the outcome categorization was evaluated by a randomly selected sample of 50 women using the random row selection function of JMP 6 software (SAS Institute Inc., Cary, NC). Random row selection is a function in JMP that allows random selection of patients from a given file of patients in which each patient is entered on a separate row. Outcomes were assigned by one of the investigators (M.R.H.), who was masked to the outcome determined by the initial chart review. The agreement in evaluation of treatment failure between the masked investigator and the initial chart review was 100% (κ=1.0, 95% confidence interval [CI], 0.9–1.0), and the agreement in measuring amenorrhea was 86% (κ=0.7, 95% CI 0.5–0.9). This was consistent with the “almost perfect” and “substantial” observer agreement for treatment failure and amenorrhea, respectively, according to Landis and Koch.13

The two global endometrial ablation methods used in Olmsted County during the study period were thermal balloon ablation (ThermaChoice; Gynecare, Somerville, NJ) and radio-frequency ablation (NovaSure; Cytyc Surgical Products, Palo Alto, CA). Women were offered the procedure if an initial trial of medical therapy for menorrhagia had failed or if medical therapy was contraindicated and they had met the U.S. Food and Drug Administration–approved inclusion criteria for global endometrial ablation. Before global endometrial ablation, all women had a thorough clinical examination, a Pap test, endometrial sampling, pelvic ultrasonography, and office hysteroscopy if structural uterine lesions were suspected. Only women with benign polyps or submucous leiomyomas not distorting the endometrial cavity or less than 2 cm in size were offered endometrial ablation; removal was by dilation and curettage (D&C) or ablation in situ. As is consistent with standard global endometrial ablation practice, women did not routinely receive hormonal or surgical pretreatment of the endometrium.

Preoperative data were obtained from patient records. History of cesarean deliveries and tubal ligation was documented. We also collected data about preoperative characteristics, procedure-related complications, and main outcome measures. To minimize measurement bias when evaluating complications during the chart review, an independent ICD-9 code search for postprocedural endometrial cancer, pregnancy, and pelvic pain was conducted. Variables were categorized for ease of interpretation. Age was categorized by using a threshold value of 45 years.8 Patients were classified as obese or not on the basis of body mass index (obesity was defined as body mass index of 30 kg/m2 or more).14 A parity threshold of 5 (the definition of grand multiparity) was used in the treatment failure model, and a parity threshold of 2 (the median parity of the study population) was used in the amenorrhea model. A 4-mm threshold for endometrial thickness was selected.9 The threshold hemoglobin value for anemia was 12 g/dL.15 For duration of bleeding, we used the median duration of 7 days as a threshold value. For uterine length, we used the median of 9 cm as the threshold value.

In the amenorrhea model, associations between amenorrhea (binary end point) and preoperative variables were evaluated by fitting logistic regression models and summarized by odds ratios (ORs) and corresponding 95% CIs. In the treatment failure model, the Kaplan-Meier method was used to estimate the cumulative treatment failure rates and corresponding 95% CIs. Cox proportional hazard models were fit to evaluate associations between demographic and preoperative variables and outcomes. Each association was summarized by a hazard ratio (HR) and corresponding 95% CI from the model estimates.

For each outcome, each preoperative variable was initially evaluated in a univariable model. Variables with a P value less than .20 in the univariable analysis were considered in multivariable modeling.16 The multivariable model was derived using backward and step-wise variable selection procedures, and variables with a P value less than .05 in the final model were retained. The type of global endometrial ablation procedure performed was included in the final multivariable model, regardless of its significance in the univariable model, to adjust for any methodologic differences. Two-way interactions between the different variables in the final model were evaluated. For the variables considered in the treatment failure model, the proportional hazards assumption was assessed separately for each variable using the scaled Schoenfeld residual method.17 This method allows evaluation of whether the covariate effect is constant over the follow-up time by visually assessing a plot of the scaled residuals against time and by examining their correlation. The discriminative ability of the final models was summarized using a concordance statistic (c index).18 A value of 1.0 for the c index indicates that the factors in the model perfectly separate patients with different outcomes, whereas a value of 0.5 indicates that the factors in the model contain predictive information equal to that obtained by chance alone.

All statistical analyses were two-tailed, and P values less than .05 were considered statistically significant. The statistical analysis was performed using SAS 8 software (SAS Institute, Inc).

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The women included in the study (N=816) underwent global endometrial ablation from January 1, 1998, through December 31, 2005. Patients were divided into two groups: 455 were in the model development cohort, and 361 were in the model validation cohort (Fig. 1). The baseline characteristics of both cohorts are shown in Table 1.



Table 1

Table 1

Of the 412 women in the amenorrhea model development cohort, 96 had postablation amenorrhea (23% of patients, 95% CI 19–28%). During the 1,201 person-year follow-up, 45 women had hysterectomies and five had reablations; the 5-year cumulative failure rate was 16% (95% CI 10–20%) (Fig. 2). All reablations were performed to treat persistent bleeding and were considered indications of treatment failure. Forty of 45 hysterectomies met our criteria for treatment failure; 28 were performed for persistent bleeding and 12 for persistent pain. Indications for the remaining five hysterectomies were not associated with the global endometrial ablation procedure (two benign ovarian masses, one uterine prolapse, one fibroid uterus, and one cervical adenocarcinoma in situ); in the analysis, these data were censored at the time of surgery.



In the final model, the following preoperative variables were significantly associated with amenorrhea: age 45 years or older (adjusted OR [aOR] 2.6, 95% CI 1.6–4.3); uterine length less than 9 cm (aOR 1.8, 95% CI 1.1–3.1); endometrial thickness less than 4 mm (aOR 2.7, 95% CI 1.2–6.3); and use of bipolar radio-frequency ablation (aOR 2.8, 95% CI 1.7–4.9) (Table 2). The c index for the final model was 0.706. No significant interactions between variables in the final model were detected. For 67 women in the radio-frequency ablation subgroup, D&C was performed to thin the endometrium before ablation; however, the difference in rates of postablation amenorrhea in those who had D&C and those who did not was not statistically significant (P = .15). Table 3 shows the predicted and observed rates of amenorrhea after applying the final model to the model validation cohort.

Table 2

Table 2

Table 3

Table 3

In the final model, the following variables were identified as independent predictors of treatment failure: age younger than 45 years (adjusted HR [aHR] 2.6, 95% CI 1.3–5.1); parity of 5 or greater (aHR 6.0, 95% CI 2.5–14.8); prior tubal ligation (aHR 2.2, 95% CI 1.2–4.0); and preoperative dysmenorrhea (aHR 3.7, 95% CI 1.6–8.5) (Table 4). The c index of the final model was 0.755. No significant interactions between variables in the final model were detected. Table 5 shows the predicted and observed cumulative treatment failure rates after applying the final model to the model validation cohort. Results were stratified by age, parity, presence of preoperative dysmenorrhea, and tubal ligation status (Fig. 3).

Table 4

Table 4

Table 5

Table 5



Complications were generally minor and infrequent. Intraoperative complications were reported in six patients (1.3%, 95% CI 0.5–2.9%), ie, five cervical injuries and one uterine perforation. Postprocedural complications were documented in three patients (0.7%, 95% CI 0.1–1.9%), ie, two cases of cystitis and one case of endometritis. After global endometrial ablation, 23 women (5.1%, 95% CI 3.2–7.5%) had pelvic pain. In nine, ultrasonograms showed evidence of fluid collection in the uterus (postablation syndrome). Of these nine patients, five had hysterectomy for persistent pain, three had evidence of hematometra, one had adenomyosis, and one had normal findings after a pathologic examination. Postprocedural pregnancy was diagnosed in three women (0.7%, 95% CI 0.1–1.9%). All pregnancies resulted in spontaneous abortions during the first trimester. In addition, no reports (95% CI 0–0.8%) of endometrial cancer or death were made after ablation.

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We performed a systematic search of the MEDLINE, EMBASE, Web of Science, and Scopus databases from inception to November 2007 by using the terms endometrial ablation and population-derived studies. According to this search, our study is the first population-derived study of the long-term outcomes and predictors of outcome for women undergoing global endometrial ablation to treat menorrhagia. The cumulative failure rate of global endometrial ablation was 16% at 5 years, and most patients with treatment failure required hysterectomy for persistent bleeding or pelvic pain. Predictors of treatment failure included age younger than 45 years, parity of 5 or greater, prior tubal ligation, and history of dysmenorrhea. Predictors of amenorrhea were age 45 years or older, uterine length less than 9 cm, endometrial thickness less than 4 mm, and use of radio-frequency ablation rather than thermal balloon ablation. Predictive models of outcomes were constructed and validated in the population-derived and referral-derived cohorts, respectively.

Regardless of a patient’s perception of menstrual pattern change after ablation, amenorrhea is an important clinical outcome. It often is the goal of menorrhagia treatment, and it is the main reason for a high level of patient satisfaction after hysterectomy.19 Conversely, failure to achieve the expected outcome of amenorrhea after endometrial ablation commonly leads to performance of hysterectomy.20 Although several studies have reported amenorrhea rates of 10% to 60% after endometrial ablation,5,21–24 this information is of limited value to specific patients. Knowing the patient-specific likelihood of amenorrhea optimizes preoperative counseling. For example, the likelihood of amenorrhea for a 48-year-old woman with a normal-sized uterus (less than 9 cm) and a thin endometrium (less than 4 mm) who undergoes radio-frequency ablation is 71%, whereas it is 6% for a 35-year-old woman with a larger uterus (9 cm or more) and thicker endometrium (4 mm or more) who undergoes thermal balloon ablation. This information may improve patient satisfaction and may reduce the need for additional intervention after ablation.

Although the overall amenorrhea rate in this study (23%) was lower than that of previously published reports,21,25 the predicted rate of amenorrhea ranged from 6% to 71% and depended on specific patient characteristics and the type of ablative technology used. Our overall rate was less likely to be confounded by menopause because only patients with amenorrhea that began immediately after the procedure were included in the analysis.21,25 For older women, development of amenorrhea may be facilitated by age-related impairment of endometrial regeneration.8,9 Although we believe the confounding effect of menopause was minimized in the current study by our definition of amenorrhea (cessation of menses immediately after surgery that lasted for at least 12 months), this bias cannot be eliminated completely without performing ovarian function tests.

Another important finding is that women who underwent radio-frequency ablation were more likely to have amenorrhea than those who underwent thermal balloon ablation. Our results are consistent with a recent study by Kleijn et al,26 who reported an amenorrhea rate of 48% in radio-frequency ablation patients compared with 32% in thermal balloon ablation patients at 5 years of follow-up. The use of impedance-based technology in radio-frequency ablation may optimize the delivery of treatment energy for more complete endometrial destruction.5,26

During preoperative counseling, patients frequently ask about the probability of hysterectomy after ablation. In one study, 60% of women who underwent hysterectomy indicated that they would have chosen endometrial ablation if the lifetime treatment failure rate was less than 20%.27 A recent clinical trial by the Surgical Treatments Outcomes Project for Dysfunctional Uterine Bleeding (STOP-DUB), which randomly assigned patients to undergo hysterectomy or endometrial ablation, reported a failure rate of more than 30% after a 4-year follow-up of the global endometrial ablation subgroup.28 The low failure rate observed in our study may be due to better patient counseling and matching patient expectations with outcomes. For example, patients who prefer complete cessation of menses after endometrial ablation for menorrhagia are more likely to undergo hysterectomy to treat bleeding symptoms of any severity.20 The randomization in the STOP-DUB study may have contributed to the higher failure rate.

Another important determinant of treatment failure is a good understanding of predictors of failure and application of that knowledge during patient selection and preoperative counseling. The model that we developed predicted clinically useful short- and medium-term rates of treatment failure after global endometrial ablation. For example, the likelihood of treatment failure for a 35-year-old woman with three prior deliveries and a history of dysmenorrhea and tubal ligation at the time of thermal balloon ablation is 70% at 5 years, whereas it would be 6% for a 48-year-old woman with the same parity but no history of dysmenorrhea or tubal ligation. Appropriate patient counseling and selection ultimately may improve treatment outcomes.

Understanding the causal relationship between age, preoperative dysmenorrhea, and tubal ligation status and treatment failure is less clear. Tubal ligation has been identified consistently as a risk factor for treatment failure during rollerball ablation,8 and the threshold for a hysterectomy may be lower in a patient who has had a tubal ligation. Perhaps as important is the association between tubal ligation and post–endometrial ablation syndrome. This syndrome is characterized by pain from the distention of the proximal end of the fallopian tube that is caused by regeneration of the cornual endometrium, intrauterine adhesions that obstruct the outflow tract, and tubal ligation that prevents emptying into the peritoneal cavity.29 However, no patients in the current study who underwent hysterectomy had a pathologic diagnosis consistent with post–endometrial ablation syndrome. The association between dysmenorrhea and treatment failure first was suggested by Bongers and colleagues,9 even though their reported association did not reach statistical significance. Undiagnosed adenomyosis may persist after ablation, cause persistent pelvic pain, and require a hysterectomy.5

Global endometrial ablation was generally safe, and minor complications occurred in less than 5% of patients. Our data compare favorably with data from the Manufacturers and Users Facility Device Experience (MAUDE) database, which reported major morbidities after global endometrial ablation.30 Endometrial cancer after endometrial ablation was described previously,31 but no such cases were documented in our study population during the relatively short follow-up period. The absence of a cancer diagnosis in the current cohort provides preliminary assurance, but longer follow-up and larger numbers of patients are needed to determine the effect of global endometrial ablation on the incidence and early diagnosis of endometrial cancer.

The main limitation of this study was its retrospective nature, which precluded objective measures of treatment outcomes such as a validated bleeding score. In addition, patient data were incomplete for some variables in the final model. However, only two preoperative variables were missing data from more than 20% of patients, and sensitivity analyses (conducted to explore the effect of the missing variables) showed that it did not affect the final model.

This study examined the experience with global endometrial ablation technologies over a relatively long period. The population-derived nature of the study allowed us to determine treatment outcomes precisely, and the minimal number of patients lost to follow-up provided a fairly complete data set. The characteristics of our study population were generally similar to those of whites in the United States, but further validation of the model in larger cohorts and in other races would be valuable.

We believe the data presented in this report can be used to optimize preoperative patient counseling. Ultimately, these data may facilitate greater use of global endometrial ablation technology when treating women with menorrhagia.

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© 2009 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.