Contents: Research LetterInvasive Cervical Cancer After a Positive Pap Test Result and Negative Human Papillomavirus Test ResultLocke, Alexander MD; Shah, Nina R. MD; Fetterman, Barbara SCT (ASCCP); Poitras, Nancy BS; Wi, Soora MPH; Castle, Philip E. PhD, MPH; Wentzensen, Nicolas MD; Kinney, Walter MD; Clarke, Megan A. PhD, MHS; Lorey, Thomas MDAuthor Information Regional Laboratory, The Permanente Medical Group, Berkeley, the Department of Obstetrics and Gynecology, The Permanente Medical Group, South Sacramento, and the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Permanente Medical Group, Sacramento, California; and the Division of Cancer Prevention and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland. Corresponding author: Thomas Lorey, MD, The Permanente Medical Group, Berkeley, CA; email: [email protected]. This study was performed as part of the Guideline development process within KPNC. Financial Disclosure Philip E. Castle has received HPV tests and assays for research at reduced or no cost from Roche, Cepheid, Becton Dickinson, and Arbor Vita Corporation. The other authors did not report any potential conflicts of interest. The opinions expressed by the authors are their own and this material should not be interpreted as representing the official viewpoint of the U.S. Department of Health and Human Services, the National Institutes of Health, or the National Cancer Institute. Each author has confirmed compliance with the journal's requirements for authorship. Peer reviews are available at https://links.lww.com/AOG/C417. Obstetrics & Gynecology: October 2021 - Volume 138 - Issue 4 - p 580-581 doi: 10.1097/AOG.0000000000004543 Buy Metrics In Brief The majority of cervical cancers after Pap test–positive, human papillomavirus test–negative co-tests are symptomatic or clinically apparent. © 2021 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.