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Improving Patient Knowledge of Aneuploidy Testing Using an Educational Video: A Randomized Controlled Trial

Mulla, Bethany M., MD; Chang, Olivia H., MD; Modest, Anna M., PhD; Hacker, Michele R., ScD; Marchand, Karen F., MS; O’Brien, Karen E., MD

doi: 10.1097/AOG.0000000000002742
Genetics: Original Research: PDF Only

OBJECTIVE: To evaluate the effectiveness of an educational video explaining aneuploidy testing.

METHODS: This was a randomized controlled trial of women with singleton pregnancies having aneuploidy testing at less than 14 weeks of gestation from September 2016 to March 2017 at our prenatal ultrasound center. We developed an educational video on aneuploidy testing. Participants, stratified by age younger than or 35 years or older at estimated delivery date, were randomized to either view or not view the video before their ultrasonogram. Participants 35 years or older also met with a genetic counselor at the ultrasound appointment. All participants completed a survey assessing knowledge of genetic testing (score of 0–15) at baseline and after the appointment. The primary outcome was change in knowledge score after the intervention. A sample size of 23 per group (n=92) was planned for a total of 46 women younger than 35 years of age and 46 women aged 35 years or older. Data are presented as median (interquartile range).

RESULTS: Of 104 eligible women who were approached, 92 were randomized. Forty women aged younger than 35 years and 41 women aged 35 years or older completed the study. Baseline characteristics were similar across groups. In women younger than 35 years, the video group had a significant improvement in knowledge score (+2.0 [1.0–5.0]) compared with the control group (0 [−1.0 to 1.0]; P=.01) and reported better understanding of the information compared with the control group (P<.001) with no change in patient satisfaction (P=.25). In women 35 years or older, change in knowledge score was similar for the video and control groups (P=.98) with no difference in self-reported understanding (P=.49) or patient satisfaction (P=.30).

CONCLUSION: A patient-centered educational video explaining aneuploidy testing options improved knowledge and self-reported understanding of the information in women younger than 35 years with no change in patient satisfaction. No difference was seen for women 35 years or older, likely as a result of genetic counseling provided to these women.

An educational video on aneuploidy testing improves knowledge and self-reported understanding in women aged younger than 35 years at delivery without a change in patient satisfaction.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, and the Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts.

Corresponding author: Karen E. O’Brien, MD, 330 Brookline Avenue, Boston, MA 02215; email:

A Shore Fellowship Grant was obtained through Harvard Medical School to fund this project. This work was conducted with support from Harvard Catalyst: The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR001102 and financial contributions from Harvard University and its affiliated academic health care centers).

Financial Disclosure The authors did not report any potential conflicts of interest.

Presented at the 38th Annual Meeting of the Society for Maternal-Fetal Medicine, January 29–February 3, 2018, Dallas, Texas.

Each author has indicated that she has met the journal's requirements for authorship.

Received March 12, 2018

Received in revised form May 03, 2018

Accepted May 10, 2018

© 2018 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.