In 2014, the Society for Maternal-Fetal Medicine, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the American Academy of Pediatrics, and the American College of Obstetricians and Gynecologists published an executive summary of a joint workshop to establish obstetric interventions to be considered for periviable births. We sought to evaluate changes in practice patterns since the publication of these guidelines.
We conducted a population-based cohort study of all singleton live births delivered between 22 0/7 and 23 6/7 weeks of gestation in the United States within two time epochs: pre–executive summary (Epoch 1: 2012–2013) and post–executive summary (Epoch 2: 2015–2016) guideline release. The primary outcome was the difference in the rate of cesarean delivery between pre–executive summary and post–executive summary guideline publication. Secondary outcomes included differences in rates of individual and composite neonatal interventions (neonatal intensive care unit admission, ventilation, surfactant and antibiotic administration), maternal adverse outcomes (intensive care unit admission, transfusion, hysterectomy, uterine rupture), and neonatal mortality. Multivariable logistic regression estimated the association of delivery epoch with outcomes.
There were 15,846,405 live births in the United States between 2012–2013 and 2015–2016, of which 14,799 (0.1%) were singletons delivered between 22 and 24 weeks of gestation. Among these live births, 7,374 (52.3%) were delivered in Epoch 1 and 7,425 (47.7%) in Epoch 2. Cesarean delivery rates increased from Epoch 1 to Epoch 2 (24.3% vs 28.4%, P<.001), which was attributable to increased cesarean utilization during the 23rd week (36.3% vs 40.8%, difference 4.5%, 95% CI 2.3–6.6). Likewise, the rate of composite neonatal interventions increased (50.6% vs 56.9%, difference 6.3%, 95% CI 4.6–8.0) between Epochs 1 and 2, in association with a slight reduction in neonatal mortality (67.2% vs 64.6%, P=.009). There was no statistically significant difference in composite (8.9% vs 9.5%, P=.261) adverse maternal outcomes between delivery epochs.
The frequency of delivery by cesarean in the 23rd week increased by 4.5% after publication of the periviable birth executive summary. The observed increase in cesarean delivery and composite neonatal interventions between delivery cohorts was associated with a small reduction in neonatal mortality.
The frequency of delivery by cesarean in the 23rd week of gestation increased by 4.5% after publication of an executive summary of guidelines on periviability.
Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, the Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, and the University of Cincinnati Department of Pediatrics, Cincinnati, Ohio.
Corresponding author: Robert M. Rossi, MD, Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, University of Cincinnati College of Medicine, Medical Sciences Building, Room 4555, 231 Albert Sabin Way, Cincinnati, OH 45267-0526; email: email@example.com.
Financial Disclosure The authors did not report any potential conflicts of interest.
This study includes data provided by the Center for Disease Control and Prevention, National Vital Statistics System, which should not be considered an endorsement of this study or its conclusions. No funding was obtained in support of this study.
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