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Primary Small Cell Neuroendocrine Tumor Within a Urethral Diverticulum

Sisler, Katelin, MD; Knutson, Alex, BS; McLennan, Mary, MD

doi: 10.1097/AOG.0000000000003054
Contents: Urogynecology: Case Report

BACKGROUND: Primary small cell neuroendocrine carcinoma of the urinary tract is a very rare cancer, accounting for fewer than 0.5% of urinary tract tumors. These are aggressive neoplasms with high rates of metastases. Urethral diverticula can be found in up to 6% of women.

CASE: A 31-year-old woman presented with a clear vaginal discharge and an anterior vaginal wall mass that was thought to be a recurrent cyst. After surgical dissection, she was noted to have a urethral diverticulum with a solid nodule at the base. Final pathology showed a high-grade small cell neuroendocrine carcinoma.

CONCLUSION: Malignancy in a urethral diverticulum can occur in young patients. Clinicians should be aware of this possibility when choosing to manage urethral lesions expectantly.

Clinicians should be aware of the possibility of malignancy in a urethral diverticulum when managing urethral lesions expectantly, even in young people.

Department of Obstetrics and Gynecology, Saint Louis University School of Medicine, and Saint Louis University School of Medicine, St. Louis, Missouri.

Corresponding author: Katelin Sisler, MD, 7354 Cornell Ave, St. Louis, MO 63130; email:

Financial Disclosure The authors did not report any potential conflicts of interest.

Each author has confirmed compliance with the journal's requirements for authorship.

Peer reviews and author correspondence are available at

Received October 25, 2018

Received in revised form October 29, 2018

Accepted November 01, 2018

© 2019 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.