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Management Strategy for Breast Cancer in Pregnancy

Kuo, Kelly, MD; Caughey, Aaron B., MD, PhD

doi: 10.1097/AOG.0000000000002647
Contents: Breast Cancer: Clinical Conundrums

A 34-year-old primigravid woman presents for a routine prenatal visit at 18 weeks of gestation with a breast lump. On examination, she has a painless, firm breast mass measuring 3–4 cm in diameter with overlying skin dimpling. A diagnostic mammogram shows findings suspicious for malignancy (Breast Imaging Reporting and Data System [BI-RADS] 4), and core biopsy demonstrates an invasive ductal carcinoma with both estrogen and progesterone receptor-positive staining. The patient asks: “How will this affect my pregnancy, and what is the safest course of action?”

Surgical staging and treatment of breast cancer should not be deferred during pregnancy, and iatrogenic prematurity should be avoided given the overall reassuring data regarding chemotherapy and perinatal outcomes.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.

Corresponding author: Kelly Kuo, MD, Department of Obstetrics and Gynecology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L466, Portland, OR 97239; email:

Financial Disclosure The authors did not report any potential conflicts of interest.

Each author has indicated that he or she has met the journal's requirements for authorship.

Received February 3, 2018. Received in revised form March 20, 2018. Accepted March 29, 2018.

© 2018 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.