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Salpingo-oophorectomy at the Time of Benign Hysterectomy

A Systematic Review

Evans, Elizabeth Casiano MD; Matteson, Kristen A. MD, MPH; Orejuela, Francisco J. MD; Alperin, Marianna MD, MS; Balk, Ethan M. MD, MPH; El-Nashar, Sherif MBBCh, MS; Gleason, Jonathan L. MD; Grimes, Cara MD; Jeppson, Peter MD; Mathews, Cara MD; Wheeler, Thomas L. MD, MSPH; Murphy, Miles MD; ; for the Society of Gynecologic Surgeons Systematic Review Group

doi: 10.1097/AOG.0000000000001592
Contents: Review
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OBJECTIVE: To compare the long-term risks associated with salpingo-oophorectomy with ovarian conservation at the time of benign hysterectomy.

DATA SOURCES: MEDLINE, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials were searched from inception to January 30, 2015. We included prospective and retrospective comparative studies of women with benign hysterectomy who had either bilateral salpingo-oophorectomy (BSO) or conservation of one or both ovaries.

METHODS OF STUDY SELECTION: Reviewers double-screened 5,568 citations and extracted eligible studies into customized forms. Twenty-six comparative studies met inclusion criteria. Studies were assessed for results, quality, and strength of evidence.

TABULATION, INTEGRATION, AND RESULTS: Studies were extracted for participant, intervention, comparator, and outcomes data. When compared with hysterectomy with BSO, prevalence of reoperation and ovarian cancer was higher in women with ovarian conservation (ovarian cancer risk of 0.14–0.7% compared with 0.02–0.04% among those with BSO). Hysterectomy with BSO was associated with a lower incidence of breast and total cancer, but no difference in the incidence of cancer mortality was found when compared with ovarian conservation. All-cause mortality was higher in women younger than age 45 years at the time of BSO who were not treated with estrogen replacement therapy (hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.04–1.92). Coronary heart disease (HR 1.26, 95% CI 1.04–1.54) and cardiovascular death were higher among women with BSO (HR 1.84, 95% CI 1.27–2.68), especially women younger than 45 years who were not treated with estrogen. Finally, there was an increase in the prevalence of dementia and Parkinson disease among women with BSO compared with conservation, especially in women younger than age 50 years. Clinical practice guidelines were devised based on these results.

CONCLUSION: Bilateral salpingo-oophorectomy offers the advantage of effectively eliminating the risk of ovarian cancer and reoperation but can be detrimental to other aspects of health, especially among women younger than age 45 years.

Bilateral salpingo-oophorectomy offers the advantage of effectively eliminating the risk of ovarian cancer and reoperation but can be detrimental to other aspects of health.

University of Texas Health Science Center San Antonio, San Antonio, Texas; Women & Infants Hospital, Alpert Medical School of Brown University, and the Center for Evidence Based Medicine, Brown University, Providence, Rhode Island; Baylor College of Medicine, Houston, Texas; the University of California, San Diego, San Diego, California; Case Western Reserve University School of Medicine, Cleveland, Ohio; Carilion Clinic, Roanoke, Virginia; Columbia University, College of Physicians and Surgeons, New York, New York; the University of New Mexico, Albuquerque, New Mexico; the University of South Carolina School of Medicine, Greenville, South Carolina; and the Institute for Female Pelvic Medicine and Reconstructive Surgery, North Wales, Pennsylvania.

Corresponding author: Elizabeth C. Evans, MD, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229; e-mail: casianoe@uthscsa.edu.

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2016 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.