The diagnosis of preterm premature rupture of membranes (PROM) is based on pooling, ferning, and Nitrazine tests; definitive diagnosis is made with a blue dye test.
A 21-year-old woman, gravida 1 para 0, at 25 5/7 weeks of gestation was admitted for preterm PROM with positive findings of pooling, Nitrazine, and ferning. Her cervix was bluish with white plaques. Amniotic fluid volume was normal. On hospital day 8, her discharge ceased; examination was negative for pooling, Nitrazine, and ferning. A blue dye tampon test was negative. A Pap test result from her hospitalization returned consistent with herpes infection.
The diagnosis of preterm PROM should be constantly reevaluated in the setting of a normal amniotic fluid volume.
The diagnosis of preterm premature rupture of membranes should be carefully reevaluated in the setting of normal amniotic fluid volume, because it may be erroneous.
Johns Hopkins Hospital Bayview Medical Center, Johns Hopkins University, Baltimore, Maryland.
Corresponding author: Christina N. Cordeiro, MD, Johns Hopkins Hospital Bayview Medical Center, Johns Hopkins University, 777 South Eden Street #1108, Baltimore, MD 21231; e-mail: email@example.com.
Financial Disclosure The authors did not report any potential conflicts of interest.