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Chronic Granulomatous Disease Carrier With Recurrent Poor Obstetric Outcome

Haidar, Ziad A. MD; Malshe, Amol MD; McKenna, David MD

doi: 10.1097/AOG.0000000000000097
Case Report

BACKGROUND: Chronic granulomatous disease is a primary immunodeficiency disorder characterized by severe recurrent bacterial and fungal infections. Female carriers of the X-linked form of the disorder usually are unaffected and rarely have serious infections.

CASE: A 22-year-old pregnant patient known to be a carrier of the X-linked form of chronic granulomatous disease had a history of chorioamnionitis during her two previous pregnancies. During her third pregnancy, she presented again with the same diagnosis, which resulted in delivery at 25 weeks of gestation.

CONCLUSION: Carriers of chronic granulomatous disease should be monitored closely during pregnancy, as if they have the disease. To decrease the risk of infectious morbidity and mortality, obstetricians should have a low threshold for starting prophylactic antibiotics early during pregnancy, even if the patient is asymptomatic.

Obstetricians caring for pregnant women who are carriers of chronic granulomatous disease should have a low threshold for starting prophylactic antibiotics.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

Corresponding author: Ziad A. Haidar, MD, FACOG, Berry Building, Ground Floor, 1 Wyoming St, Dayton, OH 45409; e-mail:

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2014 by The American College of Obstetricians and Gynecologists.