Chronic granulomatous disease is a primary immunodeficiency disorder characterized by severe recurrent bacterial and fungal infections. Female carriers of the X-linked form of the disorder usually are unaffected and rarely have serious infections.
A 22-year-old pregnant patient known to be a carrier of the X-linked form of chronic granulomatous disease had a history of chorioamnionitis during her two previous pregnancies. During her third pregnancy, she presented again with the same diagnosis, which resulted in delivery at 25 weeks of gestation.
Carriers of chronic granulomatous disease should be monitored closely during pregnancy, as if they have the disease. To decrease the risk of infectious morbidity and mortality, obstetricians should have a low threshold for starting prophylactic antibiotics early during pregnancy, even if the patient is asymptomatic.
Obstetricians caring for pregnant women who are carriers of chronic granulomatous disease should have a low threshold for starting prophylactic antibiotics.
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.
Corresponding author: Ziad A. Haidar, MD, FACOG, Berry Building, Ground Floor, 1 Wyoming St, Dayton, OH 45409; e-mail: email@example.com.
Financial Disclosure The authors did not report any potential conflicts of interest.