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Using a Multivariate Index Assay to Assess Malignancy in a Pelvic Mass

Kim, Kenneth H. MD; Alvarez, Ronald D. MD

doi: 10.1097/AOG.0b013e318242b4e0
Current Commentary

A multivariate index assay recently was developed to assist physicians in the assessment of the risk of ovarian cancer in women with pelvic masses undergoing operative intervention. Its aim is to improve the identification of patients with ovarian malignancy so that these patients can be appropriately referred to a subspecialist with ovarian cancer–management expertise, thereby affording the opportunity for improved outcome. This commentary questions the need to obtain a multivariate index assay test in all women with pelvic masses who are scheduled for operative intervention. Common-sense guidelines for more judicious use of this new triage test in the evaluation of these patients also are provided.

With its recent inception, there is potential for misuse of a new multivariate index assay in the assessment of malignancy in a pelvic mass.

From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama.

Corresponding author: Kenneth H. Kim, MD, The University of Alabama at Birmingham, Division of Gynecologic Oncology, 176F, Rm 10250, 619 19th Street South, Birmingham, AL 35211; e-mail:

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2012 by The American College of Obstetricians and Gynecologists.