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Clopidogrel Use Throughout Pregnancy in a Patient With a Drug-Eluting Coronary Stent

Myers, G. Robert MD; Hoffman, Matthew K. MD; Marshall, Erik S. MD, FACC

doi: 10.1097/AOG.0b013e318213d024
Case Reports
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BACKGROUND: Little information regarding the potential implications of drug-eluting stents and clopidogrel on pregnancy exists.

CASE: We report a case of a 27-year-old woman who received a drug-eluting coronary stent for an acute myocardial infarction and was started on clopidogrel as treatment. She was on clopidogrel when she conceived and delivered a child by cesarean. Her postpartum course was complicated by postoperative bleeding requiring transfusion.

CONCLUSION: This case highlights the perinatal and peripartum concerns of these interventions in women of childbearing age. It suggests that cesarean delivery is associated with an elevated risk of perioperative bleeding and may best be approached like other surgical procedures, with the optimal timing of surgery, when feasible, being 5 or more days after the discontinuation of clopidogrel.

A young woman taking clopidogrel throughout pregnancy and cesarean delivery experienced postoperative bleeding requiring transfusion.

From Christiana Care Health System, Newark, Delaware.

Corresponding author: G. Robert Myers, MD, Section of Cardiology, Rm 2E99, 4755 Ogletown-Stanton Road, Newark, DE 19718; e-mail: gmyers@christianacare.org.

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2011 The American College of Obstetricians and Gynecologists