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Prenatal Diagnosis of Obstructive Hydrocephalus Associated With Parvovirus B19 Infection

Zajicek, Michal MD; Gindes, Liat MD; Hoffmann, Chen MD; Morag, Iris MD; Achiron, Reuven MD

doi: 10.1097/AOG.0b013e3181e7597e
Case Reports

BACKGROUND: Intrauterine parvovirus B19 infection is a well-known cause for hydrops fetalis and fetal demise. We present a case of isolated fetal obstructive hydrocephalus caused by an intrauterine parvovirus B19 infection.

CASE: A 23-year-old woman, gravida 3 para 2, was referred for fetal obstructive hydrocephalus. Although there were no signs of fetal anemia, increased maternal parvovirus B19-specific immunoglobulin G and immunoglobulin M raised the suspicion of fetal infection. This was confirmed by polymerase chain reaction in the amniotic fluid. Elective cesarean delivery was performed at 34 weeks of gestation, followed by craniotomy and placement of shunt. At the age of 20 months, the child's development was in accordance with his age, with the exception of gross motor function, which was moderately delayed.

CONCLUSION: Evaluation of fetal obstructive hydrocephalus should include maternal serological tests for parvovirus B19.

Antenatal obstructive hydrocephalus may be associated with parvovirus B19 infection, and maternal serologic tests should be part of the evaluation.

From The Chaim Sheba Medical Center, Tel Hashomer, Department of Obstetrics and Gynecology, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv Israel.

The authors thank Asaf Lerner, MD, for his contribution to the manuscript.

Corresponding author: Michal Zajicek, Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel; e-mail:

Financial Disclosure The authors did not disclose any potential conflicts of interest.

© 2010 The American College of Obstetricians and Gynecologists