Multiple viruses have been associated with carcinogenesis in solid-organ transplant patients. Although Epstein-Barr virus (EBV) has been associated with lymphomas in immunocompromised patients, an association with smooth muscle tumors recently has been described.
An EBV immunoglobulin G–positive woman underwent bilateral lung transplant for sarcoidosis. She was placed on immunosuppression and prophylaxis for opportunistic infections. She presented 5 months later with an EBV-positive uterine leiomyosarcoma. Postoperative therapy included a decrease in immunosuppression and antiviral therapy. Recurrence was noted after 1 year; the patient developed sepsis while undergoing chemotherapy and declined further therapy.
Epstein-Barr virus–associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.
Epstein-Barr virus-associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.
From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington; the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington Hospital Medical Center, Washington, DC and; the Advanced Lung Disease and Transplant Center, Inova Fairfax Hospital, Falls Church, Virginia.
Corresponding author: Jan Sunde, MD, Madigan Army Medical Center, Department of Obstetrics and Gynecology, Building 9040, Fitzsimmons Drive, Tacoma, WA 98431; e-mail: firstname.lastname@example.org.