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Successful Management of a Leiomyomatosis Peritonealis Disseminata With an Aromatase Inhibitor

Takeda, Takashi MD, PhD1,2; Masuhara, Kanji MD, PhD2; Kamiura, Shouji MD, PhD2

doi: 10.1097/AOG.0b013e318180219b
Case Reports

BACKGROUND: Leiomyomatosis peritonealis disseminata is a rare disease characterized by multifocal proliferation of smooth muscle-like cells that are histologically similar to uterine leiomyoma. High levels of female gonadal steroids are considered to play an important role in the pathogenesis of leiomyomatosis peritonealis disseminata.

CASE: A 68-year-old woman was referred to our hospital for pelvic tumor and multiple intraabdominal solid masses. After laparotomy, she was diagnosed as having leiomyomatosis peritonealis disseminata. Most of the disseminated tumors were nonresectable. Raloxifene was ineffective for the control of these tumors. Anastrozole was effective for the control of tumor growth and her symptoms.

CONCLUSION: Anastrozole was useful for the management of postmenopausal nonresectable leiomyomatosis peritonealis disseminata. It is possible that the condition produces estrogen in situ, which promotes its growth in an autocrine/paracrine fashion.

Aromatase inhibitor is effective for the management of a postmenopausal woman with leiomyomatosis peritonealis disseminata.

From the 1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan; and the 2Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

Corresponding author: Takashi Takeda, MD, PhD, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; e-mail:

Financial Disclosure The authors have no potential conflicts of interest to disclose.

© 2008 The American College of Obstetricians and Gynecologists