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Prenatal Diagnosis of Anoxic Cerebral Lesions Caused by Profound Fetal Anemia Secondary to Maternal Red Blood Cell Alloimmunization

Carbonne, Bruno MD1,2; Nguyen, Amélie MD2; Cynober, Evelyne MD2; Castaigne, Vanina MD2; Cortey, Anne MD1; Brossard, Yves MD1

doi: 10.1097/AOG.0b013e3181656a11
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BACKGROUND: The long-term neurological prognosis of severe fetal anemia is usually considered favorable, especially when fetal hydrops regresses after successful in utero transfusion.

CASES: We report two cases of prenatally diagnosed fetal cerebral anoxic lesions associated with severe fetal anemia despite appropriate and successful treatment by in utero transfusion. The two pregnancies were terminated.

CONCLUSION: Profound fetal anemia may cause anoxic lesions of the fetal brain that may be diagnosed prenatally. If new onset ventriculomegaly is observed on ultrasonography after in utero transfusion for severe fetal anemia, anoxic lesions could be suspected.

Profound fetal anemia may cause anoxic lesions of the fetal brain that may be diagnosed prenatally.

From 1Centre National de Référence en Hémobiologie Périnatale, Hôpital Saint-Antoine, Paris, France; 2Service de Gynécologie Obstétrique, Hôpital Saint-Antoine, Assistance Publique – Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.

Corresponding author: Pr. Bruno Carbonne, Service de Gynécologie-Obstétrique, Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France; e-mail: bruno.carbonne@sat.aphp.fr.

Financial Disclosure The authors have no potential conflicts of interest to disclose.

© 2008 The American College of Obstetricians and Gynecologists