Cyclosporine is known to be excreted in breast milk, but levels in infants are not known. Post-transplant breast-feeding has been contraindicated in mothers treated with calcineurin inhibitors such as cyclosporine.
A 35-year-old woman exclusively breast-fed her infant during the first 10.5 months of life while she was being treated with cyclosporine. Cyclosporine measurements in infant and maternal blood and breast milk revealed a mean breast milk/maternal blood level ratio of 84%, but undetectable levels in the infant. The infant grew and developed normally.
The infant of a cyclosporine-treated mother was breast-fed exclusively during the first 10.5 months of life and did not absorb a detectable amount of the drug. Fetal growth and development were normal.
The infant of a cyclosporine-treated mother does not absorb a detectable amount of drug while being breast-fed exclusively.
Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington; and Department of Obstetrics and Gynecology and Medicine, School of Medicine, University of Washington, Seattle, Washington.
Address reprint requests to: Kristina Thiagarajan, PhD, RN, Department of Biobehavioral Nursing and Health Systems, University of Washington, School of Nursing, Box 357266, Seattle, WA 98195. E-mail: email@example.com
Supported by the Biohavioral Nursing Research Training Grant T32NRO7106. The authors acknowledge support and assistance by pediatrician, Donna Smith and lactation consultant, Ginna Wall.
Received September 15, 2000. Received in revised form December 12, 2000. Accepted January 12, 2001.