Leiomyomatosis peritonealis disseminata has been attributed to estrogen stimulation and is seen only rarely in postmenopausal women. In such cases, pathogenesis is uncertain.
Leiomyomatosis peritonealis disseminata tumors were resected from a postmenopausal woman. She was receiving tamoxifen therapy for breast cancer and had bilateral ovarian Brenner tumors. Estrogen and progesterone receptors were detected. Immunohistochemical analysis indicated that LH receptors were present.
Luteinizing hormone receptors were identified in leiomyomatosis peritonealis disseminata in one woman. Levels of FSH and LH increase after menopause, and immunohistochemical analysis showed the presence of LH receptors, so gonadotropin rather than estrogen stimulation might have contributed to development of leiomyomatosis peritonealis disseminata in this uncommon case.
Luteinizing hormone receptors identified in leiomyomatosis peritonealis disseminata might be involved in its pathogenesis in postmenopausal women.
Department of Surgery, Newark Beth Israel Medical Center, Newark, New Jersey; the Department of Surgery, Monmouth Medical Center, Long Branch, New Jersey; Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York; the Center for Human Reproduction–New Jersey, Westwood, New Jersey; and the Division of Basic Science Research, Laboratory of Molecular Reproductive Biology and Medicine, Department of Obstetrics and Gynecology, University of Louisville Health Sciences Center, Louisville, Kentucky.
Address reprint requests to: Vasilios T. Goudas, MD, Department of Obstetrics and Gynecology, New York Medical College of Valhalla, Valhalla, NY 10595
Supported in part by a grant from Serono Laboratories Inc.
Received May 13, 1999. Received in revised form September 14, 1999. Accepted October 1, 1999.