To determine if microalbumin excretion can predict the development of premature delivery.
The possibility of predicting, early in pregnancy, the development of a preterm delivery using urinary albumin was investigated in 1422 nulliparous women recruited prospectively. A first morning urine sample was collected at three occasions during pregnancy (8–14, 15–24, 25–24 weeks' gestation) for the determination of urinary albumin excretion.
No significant correlation was found between gestational age and urinary albumin (absolute concentration, albumin-creatinine ratio, or relative clearance of albumin) at either visit (r ranging from −0.043 to 0.036; P > .1). The incidence of preterm birth was similar for the first and fourth quartiles of the urinary albumin-creatinine ratio for the second visit (5.8 and 5.7%, respectively).
Urinary albumin is not a useful marker of preterm birth in a low-risk general population.