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RICO H MD PhD; COSTALES, C MD; CABRANES, J A MD, PhD; ESCUDERO, M MD, PhD
Obstetrics & Gynecology: June 1990
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Osteocalcin was evaluated by radioimmunoassay at the time of delivery in mothers and in the umbilical arteries of newborns in a group of pregnant drug users (eight heroin users and seven cocaine users) and compared with findings from a group of normal mothers and their newborns (N=18). Drug users had lower osteocalcin values than did the normal women (1.3 ± 0.7 versus 2.7 ± 0.8 ng/mL, P<.001); and infants of drug users had lower values than normal infants (14.1 ± 3.8 versus 19.0 ± 4.0 ng/mL, P<.005). The birth weights of drug users' infants were smaller (3160 ± 402 versus 3591 ± 374 g, P<.05) and there was a significant negative correlation (P<.001) between osteocalcin and drug intake during pregnancy, but no changes in osteocalcin dependent on the type of drug used. These results suggest a toxic effect of these drugs on the osteoblast, which could account for the lower birth weights and skeletal alterations reported in the infants of drug users

© 1990 The American College of Obstetricians and Gynecologists