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REECE E ALBERT MD; COLE, SOPHIE W. MD; ROMERO, ROBERTO MD; GABRIELLI, SANDRO MD; O'CONNOR, THERESA Z. MPH; HOBBINS, JOHN C. MD
Obstetrics & Gynecology: September 1989
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The modern management of pregnancy complicated by erythroblastosis fetal is is based on serial amniocenteses followed by either intrauterine transfusions or early delivery of affected infants, depending on the gestational age. A retrospective study was undertaken involving 92 isoimmunised pregnancies in which ultrasonography and amniotic fluid analyses were used to assess the relative predictive values for neonatal complications. Our data demonstrated that ultrasonography and optical density analyses were comparable in the evaluation of the isoimmunized pregnancy. The combined information from both these modalities did not increase the predictive value over that observed with either one alone. Both instruments were found to have high negative predictive values. However, neither method, used singly or in combination, was highly predictive of neonatal complications. In light of the low positive predictive values, caution should be excersized in using the results of amniotic fluid spectral analyses and /or ultrasound examinations for predicting perinatal complications

© 1989 The American College of Obstetricians and Gynecologists