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Obstetrics & Gynecology: December 1983
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Prolactin response to an intravenous injection of 5 mg of metoclopramide was monitored in 1) normal subjects during the follicular and luteal phases of the menstrual cycle; 2) subjects with known prolactinomas, two of whom were breast-feeding; 3) subjects with suspected prolactinomas; 4) normal lactating women; and 5) normal postmenopausal women. The magnitude of prolactin released was greater in the luteal than in the follicular phase controls (P < .001), the estrogen status being important, as further seen in the postmenopausal group. Comparison of responses in the prolactinoma and control groups is a useful diagnostic tool when assessing the possibility of a prolactinoma. Comparison of physiologically hyperprolactinemic subjects (lactating women) with pathological ones (prolactinomas) suggests that the main mode of metoclopramide's prolactin-releasing action is mediated via dopamine antagonism, though a small direct action on the lactotroph is possible

© 1983 The American College of Obstetricians and Gynecologists