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DENNERSTEIN LORRAINE MBBSPhD; BURROWS, GRAHAM D. MD,ChB; WOOD, CARL MB,BS; HYMAN, GRAEME BA
Obstetrics & Gynecology: September 1980
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This study was planned to determine the effects of estrogen and progestogen on female sexual behavior. Forty-nine women who had undergone hysterectomy and bilateral salpingo- oophorectomy took part in a double-blind placebocontrolled cross-over study. Over a 12-month period each woman received 3 months each of ethinyl estradiol, 50 jug per day; levonorgestrel, 250 jug per day; combination of these 2 substances (Nordiol); and a placebo. Significant differences between medications were found in sexual desire, enjoyment, and orgasmic frequency. The most beneficial effects occurred during medication with ethinyl estradiol. There were no differences observed in the effect of hormones or placebo on coital rate or on the analogue rating scales scored daily. The validity of this scale in the present study is questionable

© 1980 The American College of Obstetricians and Gynecologists