Dopamine was administered to pregnant ewes at randomly selected rates of 1, 3, 5, 10, 20, 30, or 40 μg/kg/min. Doses less than 10 μg/kg/min produced no significant change in maternal arterial blood pressure, cardiac output, or renal or uterine blood flow. Higher doses increased maternal cardiac output and blood pressure, did not change renal blood flow, but decreased uterine blood flow. Dopamine consistently caused mild maternal and fetal respiratory acidosis.
Supported in part by U. S. Public Health Research Training Grant ST1 GM0063-18 and U. S. Public Health Services Anesthesia Research Center 5P01 GM15571-8.
© 1978 The American College of Obstetricians and Gynecologists