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MADDEN JAMES D. MD FACOG; MacDONALD, PAUL C. MD, FACOG
Obstetrics & Gynecology: February 1978
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The purpose of the present study was to quantify the rates of production and to define the mechanism(s) of origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17β synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen.

© 1978 The American College of Obstetricians and Gynecologists