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HENRY GEORGE MD; WEXLER, PAUL MD, FACOG; ROBINSON, ARTHUR MD, FAAP
Obstetrics & Gynecology: November 1976
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The procedure of amnioccntcsis during the second trimester of pregnancy for genetic diagnosis creates the potential for Rh sensitizalion secondary to fetomaternal bleeding. We have advised administration of Rh-immune globulin after such amniocentesis whenever the pregnancy may be Rh-incompatible. Of 56 patients who received Rh-immune globulin there has been only 1 case of Rh sensitization, which occurred in a patient who underwent a second amniocentesis 2 weeks after the first attempt without receiving a second dose of Rh-immune globulin. There have been no developmental problems detected to date which could be ascribed to Rh-immune globulin.

© 1976 The American College of Obstetricians and Gynecologists