Following acute episodes of anteprtum pyelonephritis, patients were followed until delivery (3 to 30 weeks), and evaluated in two groups. The first group consisted of those patients maintained on antibiotic therapy during, and for only 2 weeks after, the acute episode. The second group consisted of those patients maintained on antibiotic therapy for the duration of their pregnancy. Both groups were followed with urine cultures. The overall incidence of recurrence of acute pyelonephritis was 18.5%. In the group of patients who did not receive suppressive antibiotic therapy, however, there was a high incidence (60%) of recurrence requiring rehospitalization. This is in contrast to the low incidence (2.7%) of recurrence and rehospitalization in the group of patients who were maintained on antibiotic suppressive therspy for the duration of the gestation (P < 0.001). Thus, from this clinical data and reports in the literature, it would seem that suppressive antibiotic therapy for the duration of the pregnancy is indicated after an episode of acute pyelonephritis.
© 1974 The American College of Obstetricians and Gynecologists