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The Dubin-Johnson Syndrome and Pregnancy

DI ZOGLIO, JOSEPH D., MD, FACOG; CARDILLO, EDWARD, MD, FACOG

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A recent case of Dubin-Johnson syndrome in pregnancy is reported and the literature is reviewed. This syndrome is characterized by chronic, familial, nonhemolytic hyperbilirubinemia, intermittent bilirubinuria and deposition of a dark melanin pigment within liver cells. Pregnancy is known to exacerbate the jaundice usually in the third trimester. Once the diagnosis is established, the management is expectant. Whether or not this syndrome results in excess fetal wastage awaits further documentation.

From the Department of Obstetrics at Providence Lying-In Hospital, Providence, Rhode Island.

Submitted for publication March 5, 1973.

© 1973 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.