In a series of 125 patients, either colposcopically-directed or random biopsies were taken for histopathologic diagnosis when cytologic smears were abnormal. To date, the cervix of 60 of 74 in the directed group and 40 of 51 in the random group has been evaluated completely by conization. Approximately 90% of the group who had directed biopsies showed no significant difference in diagnosis when compared with the definite cone. In the random group, 17.5% had significantly more advanced disease on conization and 50.0% had some degree of more advanced stage of neoplasia at final diagnosis than was made at random biopsy. With strict adherence to limiting criteria for selecting patients who require cervical conization, colposcopy and directed biopsy in the remainder might effectively replace conization in almost 90% of women with abnormal smears.
© 1972 The American College of Obstetricians and Gynecologists