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Obstetrics & Gynecology: September 1971
Original Article: PDF Only

Gonadoblastomas are described in two siblings, aged 18 and 26 years, who were both phenotypic nonvirilized females with amenorrhea and gonadal dysgenesis. Both patients were chromatin negative. The karyotype was 46 XY in one; the other patient refused permission for chromosome studies. Both patients had bilateral tumors. In three of the tumors, the gonadoblastoma was overgrown by dysgerminoma; the remaining tumor was composed of pure dysgerminoma. Both patients are well and free of recurrence 11 years after the excision of the tumors. Thus, for patients with gonadoblastoma, even a tumor overgrown by dysgerminoma, the prognosis is good if the neoplasm is totally removed.

© 1971 The American College of Obstetricians and Gynecologists