Urinary estriol values during pregnancy were below normal on one or more occasions in 5 of 10 patients whose fetuses had Down's syndrome. The obstetric records of 100 patients delivered of such infants showed that the incidences of fetal distress and intrauterine growth retardation were not significantly increased. Mothers of mongols had an increased incidence of antenatal complications which tend to be associated with low estriol excretion. Mongolism per se is not associated with poor fetoplacental function.
© 1970 The American College of Obstetricians and Gynecologists