The clinical and pathologic features of 10 female patients with leukoplakia of the bladder, including 3-5 years of follow-up, have been presented. Of the 10 patients, 4 were asymptomatic and the lesion was an incidental finding in cystoscopic examination prior to gynecologic evaluation. Resection and fulguration constitute treatment. None of the patients developed vesical carcinoma. Of the 10 patients 4 had associated squamous cell carcinoma of a genital organ, suggesting multicentric origins and emphasizing the value of investigating the urinary tract in patients with leukoplakia or carcinoma of the genital tract, and vice versa.