The Impact of Simulation-Based Trabeculectomy Training on Resident Core Surgical Skill Competency : Journal of Glaucoma

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Advances in Glaucoma: Original Studies

The Impact of Simulation-Based Trabeculectomy Training on Resident Core Surgical Skill Competency

Annoh, Roxanne FRCOphth, MSc*; Buchan, John MD, FRCOphth*; Gichuhi, Stephen PhD, MMed (Oph); Philippin, Heiko MD*,‡; Arunga, Simon PhD, MMed (Oph)*,§; Mukome, Agrippa MMed (Oph) MBChB; Admassu, Fisseha PhD, MMed; Lewis, Karinya FRCOphth#,**; Makupa, William MMed (Oph) MBChB††; Otiti-Sengeri, Juliet MMed (Oph) MBChB‡‡; Kim, Min MSc§§; MacLeod, David PhD, MSc§§; Burton, Matthew J. PhD, FRCOphth*,∥∥; Dean, William H. PhD, FRCOphth*,¶¶

Author Information
Journal of Glaucoma 32(1):p 57-64, January 2023. | DOI: 10.1097/IJG.0000000000002114
  • Open

Abstract

Glaucoma is the leading cause of irreversible blindness, affecting ~76 million people worldwide in 2020.1 Recent estimates suggest that over 100 million people will be diagnosed with the condition by 2040, largely because of an increasing and aging global population.1 Primary open angle glaucoma (POAG), in particular, develops earlier in those of African ancestry, with a more aggressive and rapid progression to advanced disease compared with other ethnic groups.2 Currently, Africa has the highest global prevalence of glaucoma and POAG, estimated at 4.8% [95% confidence interval (CI), 2.6–8.0] and 4.2% (CI, 2.1–7.4), respectively, in those aged 40–80 years.1 Importantly, glaucoma is responsible for 4.4% (CI, 4.1–5.0) of all blindness in Africa, which is proportionately much higher than other regions in the world.3 Urgent public health measures are therefore required to control and reduce the disease burden in the region.

The most effective way to slow the rate of disease progression in glaucoma is by targeted lowering of intraocular pressure (IOP). This is typically done using a stepwise approach, depending on the subtype of disease, the extent of optic nerve damage, and the degree of visual field dysfunction. Yet, in sub-Saharan Africa (SSA), the management of glaucoma is challenging for several reasons: late diagnosis, poor adherence to treatment, and limited access to health care services and treatment.2,4,5 Furthermore, a profound lack of patient awareness about the condition means that those affected often present with advanced, irreversible sight loss. In POAG, the initial step in treatment is medical, using long-term topical drop therapy, but in SSA, this is confounded by barriers in affordability, adherence, and side effects.4,6 Laser therapy, such as selective laser trabeculoplasty, is effective in lowering IOP and offers an alternative and safe initial treatment for African individuals with mild to moderate glaucoma.7,8 However, the IOP lowering effect from laser treatment is only temporary, with many requiring repetitive treatment or initiation of medical or surgical therapy later in life. Furthermore, its efficacy in advanced disease remains unclear. For these reasons, surgical management of glaucoma, in the form of trabeculectomy, is often recommended as the first-line choice in SSA.9

Trabeculectomy remains the gold standard surgical procedure and is the most effective technique for long-term IOP management.6,10 However, the provision of trabeculectomy depends on the availability of ophthalmic surgeons with surgical proficiency. At present, there is a global shortage of ophthalmologists, with a disproportionate shortage of ophthalmologists in SSA (an average ratio of 2.5 per million population, against a global average of 31.7) that are mostly confined to urban areas.11,12 Because of the magnitude of disease burden and high general patient workload, ophthalmologists are often denied the opportunity for subspecialist training in glaucoma, resulting in a paucity of glaucoma surgical skills.11 These challenges, coupled with a low uptake of surgical treatment, a fear of surgical complications and challenges in postoperative care, make many ophthalmologists reluctant to offer trabeculectomy as a first-line treatment option to patients.11,13

A practical solution is to enhance the existing surgical skill set of current and prospective ophthalmologists in SSA. There is widespread variability in the number of trabeculectomies performed during residency, with a mean of 4 (median of 1) in a recent survey of resident ophthalmologists in the Eastern, Central, and Southern African region.14 Qualitative analysis found that residents in the region expressed a need for improvement in conventional ophthalmic surgical training, with better supervision and more use of simulation-based surgical education (SBSE).14 Conventional ophthalmic surgical teaching in SSA typically uses theoretical-based learning, observation, low use of SBSE (mostly using low to moderate-fidelity simulation models), followed by live surgical teaching for advanced skill development.15 Importantly, the use of SBSE varies across the different training institutions in the region and is not uniformly integrated into ophthalmic surgical training. For those using SBSE in their ophthalmic surgical training, many report inadequacy of training facilities and tools, as well as a lack of trainer supervision.15 Yet, compared with the traditional Halstedian apprenticeship model of “see one, do one, teach one,” SBSE offers a safer alternative for junior surgeons to refine their skills in the absence of patient harm, by using artificial training models. It is associated with less error rate, improvement in skill acquisition, and fewer intraoperative complications.16–19 Yet, although there is extensive research in simulation techniques for cataract surgery, data on SBSE in glaucoma surgery are limited. At the time of writing, there is no known integrated, comprehensive SBSE course on surgical trabeculectomy in SSA. The GLAucoma Simulated Surgery (GLASS) trial is the first known randomized controlled trial (RCT) assessing the efficacy of intense SBSE in glaucoma surgery on overall surgical competence, confidence, and live trabeculectomy surgery output in SSA-based resident ophthalmologists.20 Here, we present a post hoc analysis of the GLASS trial data, which evaluates the impact of SBSE on core trabeculectomy surgical skill competency in resident ophthalmologists.

MATERIALS AND METHODS

Study Design

This is a post hoc analysis from the GLASS trial, which is a randomized controlled parallel-group efficacy trial conducted between October 2017 and July 2019. Trial participants were randomized to 2 arms, with intended 1:1 allocation ratio. The trial design and primary results have been fully presented elsewhere.20,21 Ethical approval was obtained from the London School of Hygiene and Tropical Medicine and the collaborating research institutions.20,21 The trial was registered (PACTR201803002159198).

Setting and Participants

Resident ophthalmologists from 6 training centers, in Kenya, Uganda, Tanzania, Zimbabwe, and South Africa, were recruited according to the inclusion criteria of having performed zero surgical trabeculectomies and assisted in <5. Participants were in their second, third, or fourth year of postgraduate ophthalmology training.

Intervention

The trial intervention was a 1-week intense trabeculectomy SBSE course. The course consisted of theoretical and practical-based teaching on glaucoma and trabeculectomy surgery. The surgical procedure was deconstructed, and instruction in surgical steps was provided using a modified Peyton 4-stage approach.20,22 Individual steps of the procedure were practiced using low-cost, moderate-fidelity simulation materials including foam materials for suturing practice and apple peels for scleral flap construction.23 A full trabeculectomy procedure was performed on high-fidelity synthetic “Advanced TrabEye” simulation surgery eyes (PS-023, Phillips Studio, Bristol, UK) and using Zeiss Stemi 305 microscopes (Carl Zeiss Microscopy, Jena, Germany) for the competency assessments. Each resident’s trabeculectomy procedure on the high-fidelity synthetic “Advanced TrabEye” was recorded using the Zeiss Labscope App (V.2.8.1) on iPads. Participants allocated to the control arm received the exact same intervention shortly after the 1-year follow-up assessment.

Outcomes

Participants were assessed on their competency in completing a full trabeculectomy procedure using the ophthalmic-simulated surgical competency assessment rubric (Sim-OSSCAR) grading tool.24 Timelines of assessment were at baseline, primary intervention (time of intervention in the intervention arm), 3 months, 1 year, time of intervention in the control arm, and 15 months (equivalent to 3 months after intervention received in the control arm, Fig. 1).

F1
FIGURE 1:
Timeline of interventions (SBSE TE course) and assessments of the primary intervention (X) and intervention in the control (x) groups using the Ophthalmic Simulated Surgical Competency Assessment Rubric tool.24 SBSE TE indicates simulation-based surgical education trabeculectomy.

Anonymized video recordings of the procedures were assessed by 2 independent, masked graders who were experts in glaucoma surgery and had undergone familiarization training using the Sim-OSSCAR tool (Fig. 2). Video recordings of procedures were allocated a random 7-digit number, being the only identifiable information available for grading. Each grader was therefore fully masked to the participant’s identity, allocation arm, training institution, and timing of surgical assessment. The primary outcome measure was the combined mean score of 3 masked assessments of simulation surgical performance over the study period in 8 selected core skills from the Sim-OSSCAR tool (Fig. 3). Each grader evaluated a minimum of 2 and maximum of 3 anonymized videos, and allocated a maximum score of 2 to each selected core surgical skill. The maximum overall score for the combined surgical skills per anonymized video was 16. Secondary outcome measures included individual core surgical skill competency scores most improved after intervention and the trends in individual core surgical skill competency scores over the 15-month study period.

F2
FIGURE 2:
Ophthalmic Simulated Surgical Competency Assessment Rubric tool for simulated trabeculectomy.25 Performance of each individual core surgical skill is ranked from 0 (novice), 1 (advanced beginner), and 2 (competent).
F3
FIGURE 3:
The GLAucoma Simulated Surgery trial core skills in trabeculectomy and assessment scores.

Statistical Analysis

The GLASS trial protocol and primary analysis included the sampling strategy, sample size, and power calculations.20,21 Intention-to-treat analysis was used for all outcome measures. The results were presented as mean±SD for parametric data, and median and interquartile range (IQR) for nonparametric data. Wilcoxon signed rank test was used for differences in combined core skill competency scores at each assessment timeline and for differences in scores between trial arms. Residents achieving maximum scores in competency in individual core surgical skill were presented as numbers and percentages, with Fisher exact test used to measure statistical significance for differences in proportions between trial arms and McNemar test for differences at each assessment timeline. All statistical analyses were conducted using STATA for Windows version 16.0 (StataCorps, Texas), with an alpha level of P<0.05 deemed as statistically significant.

RESULTS

Fifty-three participants were assessed for the eligibility for the GLASS trial during the study period. Two participants were excluded prerandomization because of prior surgical experience. Fifty-one participants were recruited and randomized, with 25 allocated to the intervention arm with 2 dropouts and 26 to the control arm. Forty-nine participants were included in the GLASS trial intention-to-treat subanalysis,20 in whom the baseline characteristics of age, sex, and time in residency were balanced.

Overall Surgical Competency in Simulated Trabeculectomy

The median combined surgical competency scores at baseline were 2.88/16 points (IQR: 1.75–4.17) and 3.25 (IQR: 1.83–4.75) in the intervention and control arms, respectively (Table 1). At primary intervention, median scores increased to 11.67 (IQR: 9.58–12.63; P=0.00001). This increase in core surgical competency scores was maintained at 3 months (median: 11.67, IQR: 10.33–13.17; P=0.00001) and at 1 year (median: 11.50, IQR: 9.67–12.67; P=0.0001) in the intervention arm. On receiving the intervention after 1 year of conventional training, median scores in the control arm increased to 11.33 (IQR: 10.67–12.50; P=0.00001). The increase was maintained at 15 months (median: 11.00, IQR: 8.17–14.00; P=0.0156). When comparing the trial arms, the difference between combined surgical competency scores at 3 months and at 1 year showed a large effect of the training intervention (P=0.00001, Table 2).

TABLE 1 - Combined Surgical Competency Scores Over the GLAucoma Simulated Surgery Trial Study Period, in Each Trial Arm
Intervention Arm Timeline n Median IQR P
Baseline 25 2.88 1.75–4.17
Primary intervention 23 11.67 9.58–12.63 0.00001*
3 mo 23 11.67 10.33–13.17 0.00001*
1 y 19 11.50 9.67–12.67 0.0001*
Control arm Baseline 26 3.25 1.83–4.75
3 mo 26 3.67 2.67–5.00 0.1443
1 y 24 4.17 3.33–5.83 0.0319
At intervention 24 11.33 10.67–12.50 0.00001*
15 mo 7 11.00 8.17–14.00 0.0156*
*P<0.05 using Wilcoxon signed rank test in reference to baseline scores.
IQR indicates interquartile range.

TABLE 2 - Combined Surgical Competency Scores Over the GLAucoma Simulated Surgery Trial Study Period, Between Trial Arms
Control Intervention
Timeline n Median IQR n Median IQR P
Baseline 26 3.25 1.83–4.75 25 3.00 1.83–4.33 0.8923
3 mo 26 3.67 2.67–5.00 23 11.67 10.33–13.17 0.00001*
1 y 24 4.17 3.50–5.83 19 11.67 9.83–12.67 0.00001*
At Intervention 24 11.33 10.67–12.50 23 11.67 9.58–12.63 0.9176
*P<0.05 using Wilcoxon rank sum test for comparison between arms. Fifteen months excluded from the analysis.
IQR indicates interquartile range.

Trends in Surgical Skill Competency Over Time

Figure 4 illustrates the mean scores of individual core surgical skill between arms. Trial participants in both arms achieved higher mean scores in core surgical skill competency on receiving the intervention. In the intervention arm, the highest score achieved was in releasable suturing at primary intervention (mean±SD: 1.77±0.42). At 3 months, the highest score was in conjunctival suturing (mean±SD: 1.87±0.22); at 1 year, the highest score was releasable suturing (mean±SD: 1.71±0.30). Conversely, mean scores in the control arm at 3 months and 1 year were similar to those at baseline. After intervention in the control arm at 1 year, the highest score was seen in conjunctival suturing (mean±SD: 1.93±0.23) and remained so at 15 months (mean±SD: 1.64±0.38). Lowest scores were achieved in speed at primary intervention (mean±SD: 0.48±0.71) and remained so at 3 months (mean±SD: 1.02±0.71) and at 1 year (mean±SD: 1.03±0.72) in the intervention arm. The lowest scores were also in speed in the control arm at the time of intervention and at 15 months (mean±SD: 0.64±0.64 and 1.14±0.69, respectively).

F4
FIGURE 4:
Mean resident competency scores by core surgical skill between arms, over time. Primary intervention denotes simulation training in the intervention arm, given shortly after baseline assessment. Intervention in the control arm occurred shortly after 1 year. Sim:OSSCAR indicates Ophthalmic Simulated Surgical Competency Assessment Rubric.

Maximum Scores in Surgical Skill Competency

Few participants achieved maximum scores in surgical skill competency before receiving the intervention (Fig. 5). At primary intervention, releasable suturing was the most competent skill achieved, with 17/23 (74%) participants in the intervention arm achieving maximum scores. This was followed by scleral flap (n=16, 70%) and scleral incision (n=15, 65%). However, the number of participants with maximum scores declined at 3 months and again at 1 year. The exception was in fluidity and speed, where participants achieving maximum scores in these skills were significantly higher at 3 months than at the time of primary intervention (χ2=6.53, P=0.0106 and χ2=8.33, P=0.0039, respectively, McNemar test). The number of participants in the control arm achieving maximum scores rose from 1 (4%) at 3 months to 3 (13%) at 1 year. After the intervention, 20 participants (83%) achieved maximum scores in conjunctival suturing, followed by releasable suturing (n=15, 63%) and scleral flap (n=10, 42%). When comparing the 2 arms, only maximum scores in conjunctival suturing were significantly different (P=0.018, Fisher exact), with the control arm achieving more maximum scores after intervention than the intervention arm had at that same point.

F5
FIGURE 5:
Number of participants achieving maximum scores in competency in surgical skills over time.

DISCUSSION

Overall Efficacy of Glaucoma Surgical Simulation

The GLASS trial is the first known international multicenter RCT to demonstrate a positive effect of glaucoma surgical simulation training on surgical competency of ophthalmology residents.20 Participants in both the control and intervention arms showed significant improvement in competency after receiving high-fidelity, intense SBSE and this effect was maintained months after the intervention. There was a significant difference in competency between the trial arms, illustrating the disparity in skill uptake between those receiving conventional ophthalmic surgical teaching and simulation-based training. Few studies are available for direct comparison. A study evaluating the efficacy of virtual-reality (VR) SBSE on resident and medical student competency in simulated pars plana vitrectomy found that those naive to simulation had longer operating times and more incidences of retinal detachments compared with those with simulation training.26 However, these findings were not statistically significant, owing to a low sample size of 14. Similarly, Solverson et al27 reported marked improvement in the error rate of novice surgeons using the Eyesi VR simulator, yet the study lacked a simulation naive comparison group or a validated means of skill assessment. As the GLASS trial used a validated scoring rubric and adopted an RCT study design, our findings strongly indicate that SBSE can have an immediate and sustained improvement in glaucoma surgical skills.

Efficacy of Glaucoma Surgical Simulation on Core Surgical Skills

In the absence of training, residents scored poorly in core skills required for modern trabeculectomy surgery such as releasable suturing. Conversely, they scored highest in scleral incision and flap formation, possibly from previous surgical experience in small incision cataract surgery.14 With conventional training alone, mean scores remained at novice level, with little progression to competent level. Yet, a significant and sustained improvement in competency was observed in both arms shortly after receiving simulation training. Importantly, skills traditionally used in trabeculectomy surgery, such as releasable suturing, sclerostomy, and conjunctival suturing, saw the biggest improvement, overall, which supports the hypothesis that targeted simulation training can refine subspecialist surgical skills. Of note, there was little change in general skills such as fluidity and speed possibly because of insufficient repetitive skill practice by residents over the course of the study. Continuous simulation practice may therefore help reduce overall trabeculectomy surgery time.

Although glaucoma SBSE led more residents to progress to competent level, the subsequent decline in competent scores in later months suggests that residents may become deskilled in acquired trabeculectomy surgical skills over time. This may be due to insufficient exposure to live trabeculectomy surgery practice in conventional training or inadequate uptake of simulation practice between follow-up assessments. Arguably, SBSE should be used to complement traditional surgical teaching rather than replace it,28 as transfer of surgical skills to the operating room can vary widely depending on the type and amount of simulation training received.18,27 Moreover, the true association between simulated training and clinical practice remains uncertain. When examining transfer of skills to live surgery, most studies have adopted a retrospective study design to investigate the effects of simulation training based on patient outcomes. For example, 1 US-based retrospective case series found significantly lower phacoemulsification complication rates in residents with VR simulation training compared with simulation-naive residents (2.4% vs. 5.1%, respectively, P=0.037).29 However, Belyea et al’s18 retrospective case review reported no significant difference in phacoemulsification complication rates between third year residents with and without VR simulation training. Prospective assessment and comparison of surgical skill competency in both simulated and live surgeries may be useful to determine the true effect of simulation training.

Limitations

This study has several limitations. First, this is a retrospective post hoc analysis of data from the GLASS trial. Therefore, the GLASS trial was not originally powered to address the hypothesis that specific skills benefit more from intense simulated-based training in trabeculectomy. As a result, the true efficacy of the intervention reported in our study may be exaggerated because of subanalyses of the original data producing falsely positive and/or negative associations between the variables. Second, although this study clearly shows superiority of glaucoma surgical simulation training over conventional training, the results only apply to simulated surgical skill competency using high-fidelity artificial eyes. In SSA, a comparison and an evaluation of ophthalmic SBSE between high-fidelity and low-fidelity models would be beneficial for reflecting clinical practice in low-income and middle-income settings. Because of low trabeculectomy case numbers in the respective training environments, it was also not possible to evaluate and compare live surgical skills with those in the simulated environment. Furthermore, the low response rate in the control group at 15 months (n=7, 26.9%) makes the findings susceptible to selection bias, distorting the true measure of effect of the intervention. This low response rate was because of trial participants completing their master of medicine (MMed) in Ophthalmology degree and no longer being able to participate in the study. The comparison of postintervention scores between the trial arms should also therefore be interpreted with caution. Finally, further detailed analysis of participants failing to achieve “advanced beginner” or “competency” Sim:OSSCAR scores after the intervention would have been beneficial to evaluate how best to refine the intervention to improve their skill set.

CONCLUSIONS

This study is the first to show a positive, immediate, and sustained impact of SBSE on key and core surgical skills in trabeculectomy. Trabeculectomy remains the most effective surgical treatment for glaucoma management in SSA but performing the procedure requires advanced microsurgical skills. Evaluating the performance of each surgical step is essential for providing targeted, constructive feedback to residents. Time taken to complete a task is a commonly used outcome measure for SBSE studies30; however, our findings suggest that the outcome measure of speed is not the best indicator of impact. The formal integration of glaucoma surgical simulation into residency program structures may result in better standards of surgical training and most importantly, improve the delivery of safe and effective glaucoma surgical treatment. Recent observations suggest that adopting surgical simulation training is widely accepted as a safer alternative to conventional surgical teaching.15 Finally, there remains very limited data on surgical trabeculectomy rates and postoperative outcomes in SSA. We therefore suggest a follow-up comprehensive, comparative analysis of trabeculectomy outcomes in centers incorporating SBSE to evaluate the real-world effectiveness of the intervention on patient glaucoma care.

ACKNOWLEDGMENTS

The authors thank Dr Catey Bunce for the comments on the quantitative analysis of the study results and Professor Colin Cook for the input into the GLASS trial.

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Keywords:

ophthalmology; training; Africa; simulation; education; glaucoma

Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.