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Effects of Axial Length and Age on Circumpapillary Retinal Nerve Fiber Layer and Inner Macular Parameters Measured by 3 Types of SD-OCT Instruments

Ueda, Kaori MD; Kanamori, Akiyasu MD, PhD; Akashi, Azusa MD; Tomioka, Mari CO; Kawaka, Yuki CO; Nakamura, Makoto MD, PhD

doi: 10.1097/IJG.0000000000000216
Original Studies

Purposes: To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments.

Methods: A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, and 3D-OCT. The cpRNFL and the macular retinal nerve fiber layer (mRNFL), the ganglion cell layer+inner plexiform layer (GCLIPL), and the mRNFL+GCLIPL ganglion cell complex, GCC thicknesses were analyzed. The correlations between these values and the axial length or age were evaluated using a partial correlation analysis. These correlations were corrected using the axial length–related magnification effect.

Results: All but the nasal quadrant cpRNFL thicknesses and GCC thicknesses obtained using the 3 OCT instruments were significantly correlated with age. The average cpRNFL thickness and GCC thickness measured using the Cirrus and RTVue, but not by the 3D-OCT, had a negative correlation with the axial length. The temporal quadrant cpRNFL thickness measured using the 3 instruments was positively correlated with the axial length. The magnification correction made the most correlations positive.

Conclusions: The average cpRNFL and GCC thicknesses measured using these 3 instruments decreased with age. The axial length affected the cpRNFL and GCC thicknesses as measured using the Cirrus and RTVue; this effect likely depended on the fundus area of analyses.

Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

Supported by the Japanese Government (A.K.), the Mishima Memorial Foundation (A.K.), and the Santen Pharmaceutical Founder Commemoration Ophthalmic Research Fund and the Uehara Memorial Foundation (A.K.).

Disclosure: The authors declare no conflict of interest.

Reprints: Akiyasu Kanamori, MD, PhD, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan (e-mail:

Received April 19, 2014

Accepted November 27, 2014

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