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Aqueous Humor Erythropoietin Levels in Patients With Primary Open-angle Glaucoma

Cumurcu, Tongabay MD*; Bulut, Yunus PhD; Demir, Helin Deniz MD*; Yenisehirli, Gulgun MD

doi: 10.1097/IJG.0b013e31804a5eb3
Original Studies
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Purpose To evaluate the levels of erythropoietin (EPO) in the aqueous humor in eyes with primary open-angle glaucoma (POAG) and without glaucoma.

Methods Levels of EPO were measured using a sandwich enzyme-linked immunosorbent assay kit in aqueous humor aspirates taken during anterior segment surgery from 45 patients, of whom 20 had POAG and 25 had senile cataract only.

Results The mean aqueous humor EPO concentration in eyes with POAG (10.91±4.32 mU/mL) was significantly higher than that from eyes with cataract (8.24±1.77 mU/mL, P=0.008). There was no significant difference between the serum EPO concentrations of POAG (26.46±10.36 mU/mL) and the control group (24.50±7.59 mU/mL, P=0.468). There was no correlation (P=0.165) between the EPO aqueous humor concentration and the EPO serum concentration while there was no correlation between the EPO aqueous humor concentration and the EPO serum concentration in the control group (P=0.819).

Conclusions The aqueous humor EPO level is increased in eyes with POAG.

Departments of *Ophthalmology

Microbiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey

Reprints: Tongabay Cumurcu, MD, Gaziosmanpasa University School of Medicine, Tokat, Turkey 60100 (e-mail: tongabay@superonline.com; tcumurcu@gop.edu.tr).

Received for publication October 4, 2006; accepted February 11, 2007

© 2007 Lippincott Williams & Wilkins, Inc.