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Serum Bile Acids in Patients with Primary Open Angle Glaucoma

Jacob, Mridula, Mariam, MBBS*; Pai. H., Vijaya, MS Ophthalmology*; Gnanaharan, John, MBBS; Kamath, Shobha, MSc, PhD Biochemistry

doi: 10.1097/IJG.0000000000000993
Original Study: PDF Only

Purpose: To measure the serum bile acids (SBA) in patients with Primary open angle glaucoma (POAG) and to compare with non-glaucomatous controls.

Patients and Methods: A hospital based case control study of 90 patients above the age of 40 years was conducted. Patients with Primary open angle glaucoma formed the study group and individuals without glaucoma in the same age group formed the control group. Serum bile acid estimation was done using ELISA kit enzymatic assay technique and the median value was compared between the two groups.

Results: The median of SBA level was found to be more in POAG patients when compared with the control group. The difference was statistically significant (P<0.001). Median SBA level was not affected by the age or gender of the participants in the study.

Conclusion: "Bile acids" may have a role in the oxidative stress and apoptosis involved in the pathophysiology of "Primary open angle glaucoma" (POAG).

*Department of Ophthalmology, Kasturba Hospital, Manipal Academy of Higher Education, Manipal, India

Department of Biochemistry, Kasturba Hospital, Manipal Academy of Higher Education, Manipal, India

Financial disclosure - No financial disclosure/conflicts of interest in the study.

Reprints: Vijaya Pai. H., MS Ophthalmology, Department of Ophthalmology, Kasturba Hospital, Manipal Academy of Higher Education, Manipal, India (e-mail: paivijaya@yahoo.co.in).

Received November 7, 2017

Accepted May 17, 2018

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