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Peripapillary Vessel Density in Glaucomatous Eyes: Comparison between Pseudoexfoliation Glaucoma and Primary Open-angle Glaucoma

Park, Ji-Hye, MD, PhD1; Yoo, Chungkwon, MD, PhD1; Girard, Michael J.A., PhD2,3; Mari, Jean-Martial, PhD4; Kim, Yong Yeon, MD, PhD1

doi: 10.1097/IJG.0000000000001062
Original Study: PDF Only

Purpose: To compare the peripapillary vessel density between eyes with pseudoexfoliation glaucoma (PXG) and eyes with primary open-angle glaucoma (POAG).

Methods: Peripapillary vessel density in the radial peripapillary capillaries (RPC) was assessed using optical coherence tomography angiography (OCTA), and compared between patients with PXG and those with POAG matched for age and mean deviation (MD) of standard automated perimetry. The vessel density was measured between the optic disc margin and 750▒μm from the optic disc margin.

Results: Thirty-nine eyes with PXG were matched to 39 eyes with POAG. Mean untreated intraocular pressure was higher in the PXG group than in the POAG group (21.4±6.7▒mm Hg vs. 14.9±2.9; P<0.001), but there was no difference in age, refractive error, visual field MD, or average retinal nerve fiber layer (RNFL) thickness between the two groups. However, the average peripapillary vessel density in the RPC was lower in the eyes with PXG than in the eyes with POAG. Moreover, there was a significant correlation between peripapillary vessel density and both visual field MD and RNFL thickness.

Conclusions: Peripapillary vessel density was lower in eyes with PXG than in eyes with POAG of similar severity.

1Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea

2Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore

3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

4University of French Polynesia, Tahiti, French Polynesia

*Reprints: Chungkwon Yoo, MD, PhD, Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul 02841, Korea (e-mail:

Disclosure: The authors declare no conflict of interest.

Received May 29, 2018

Accepted August 9, 2018

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