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Melatonin Levels in Patients with Primary Open Angle Glaucoma with High or Low Intraocular Pressure

Kim, Jung Yong, MD; Jeong, Ah Reum, MD; Chin, Hee Seung, MD, PhD; Kim, Na Rae, MD, PhD

doi: 10.1097/IJG.0000000000001130
Original Study: PDF Only

Purpose: To evaluate circulatory melatonin levels by assessing nocturnal urinary excretion of 6-sulfatoxymelatonin (aMT6s) in patients with primary open angle glaucoma (POAG) and to compare the high-tension group and the low-tension group.

Methods: This study included 80 eyes of 41 POAG patients and 87 eyes of 44 control subjects. POAG group was further classified into high-tension group and low-tension group according to the pretreatment intraocular pressure. The first urine in the morning was collected and aMT6s were measured using a commercial ELISA kit. Urinary aMT6s levels were expressed as ng aMT6s/mg creatinine. Differences in melatonin levels among the control and POAG subgroups were evaluated by generalized estimating equation adjusting age, sex, sleep duration, and inter-eye correlation.

Results: Urinary aMT6s/creatinine ratio did not differ between POAG and control group (P=0.097). The difference in the aMT6s/creatinine ratio between the three groups— high-tension group with baseline intraocular pressure (IOP) ≥21▒mmHg (19.74±3.12▒ng/mg), low-tension glaucoma group with baseline IOP < 21▒mmHg (26.71±3.47▒ng/mg), and control group (30.35±3.05▒ng/mg)—was statistically significant (P=0.046). Post hoc analysis revealed that the difference between the control and high-tension glaucoma groups was significant (P=0.014), while the difference between the control and low-tension glaucoma groups was not (P=0.436).

Conclusion: This study found low melatonin levels in high-tension glaucoma compared with the control.

Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of Medicine, Incheon, Korea

Jung Yong Kim and Ah Reum Jeong: Both authors contributed equally.

Presentation: This study was presented at the 112th Annual Meeting of the Korean Ophthalmological Society 2014.

Disclosure Statement: No competing financial interests exist for any of the authors.

Reprints: Na Rae Kim, MD, PhD, Department of Ophthalmology, Inha University Hospital, 27, Inhang-ro, Jung-gu, Incheon, Republic of Korea, 22332 (e-mail:

Received February 23, 2018

Accepted October 13, 2018

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