Repeated ultrasound cycloplasty (UCP) procedures are valuable options in patients with early or delayed intraocular pressure (IOP) increase after a first procedure. The safety of a second procedure is similar to that of the first one.
The purpose of this study was to evaluate the efficacy and safety of repeated UCPs in patients with early or delayed IOP increase after a first procedure.
Patients and Methods:
Thirty-one eyes with open-angle glaucoma, with an IOP decrease,>20% after a first UCP procedure (1 and/or 2 mo visit), and with an early or delayed IOP increase (IOP decrease<20% compared with baseline before or after the first 6 mo, respectively), underwent a second UCP procedure. Examinations were performed at 1 day, 1 week, 1, 2, 3, 6, and 12 months. Primary outcomes were surgical success (IOP reduction≥20% and IOP>5 mm Hg) at the last follow-up and vision-threatening complications. Secondary outcomes were mean IOP at each visit, medication use, and other surgical interventions.
In the group with early IOP increase, IOP was reduced (P<0.05) from a mean value of 29.8±8.2 mm Hg before retreatment (n=3.3 medications) to 18.5±7.4 mm Hg at the last follow-up (n=3.5 medications) (−34%). Success was achieved in 52.6% of eyes (10/19) at the last follow-up visit. In the late IOP increase group, IOP was reduced (P<0.05) from a mean value of 31.9±6.6 mm Hg before retreatment (n=4.0 medications) to 16.2±5.2 mm Hg at the last follow-up (n=4.0 medications) (−43%). Success was achieved in 55.5% of eyes (5/9) at the last follow-up visit. No major intraoperative or postoperative complications occurred.
A second UCP procedure could be considered in subjects with early or delayed failure after a first procedure.