The Bruch membrane opening (BMO) was posteriorly bowed and the degree of nonplanarity increased in stable and progressive glaucoma subjects. BMO became more posterior relative to the Bruch membrane (BM) in control and both stable and progressive glaucoma subjects.
To investigate longitudinal changes in morphologic characteristics of the BMO in control and glaucomatous subjects.
A total of 53 myopic eyes (17 control, 6 suspect, 20 stable glaucoma, and 10 progressing glaucoma) were followed for an average of 4.2±1.4 years and imaged at the baseline and 2 follow-up appointments using a 1060 nm swept-source optical coherence tomography system. BM and BMO were segmented, and 4 morphometric BMO parameters (area, ellipse ratio, nonplanarity, and depth) were measured.
There were no significant changes in BMO area or ellipse ratio for all groups. BMO nonplanarity was shown to increase in the glaucoma groups. BMO depth relative to BM increased in all groups except the suspects (control: 8.1 µm/y, P=0.0001; stable glaucoma: 3.5 µm/y, P=0.0001; progressing glaucoma: 14.0 µm/y, P=0.0026). In linear mixed-model analysis, axial length was positively associated with BMO area in all groups except for progressing glaucoma, and with BMO nonplanarity in stable glaucoma. It was not a significant factor to the slopes of the BMO parameters in the ANCOVA analysis of slopes.
Longitudinally, BMO increased in nonplanarity in the glaucoma eyes, and its axial position relative to BM became more posterior in both control and glaucoma eyes.
*Faculty of Medicine
‡Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver
†School of Engineering Science, Simon Fraser University, Burnaby, BC, Canada
Supported by the Michael Smith Foundation for Health Research, Vancouver, Canada; Natural Sciences and Engineering Research Council of Canada, Ottawa, Canada; Canadian Institutes of Health Research and National Health, Ottawa, Canada; Brain Canada, Montreal, Canada.
Disclosure: The authors declare no conflict of interest.
Reprints: Sieun Lee, PhD, 8888 University Drive, Burnaby, BC, Canada V5A 1S6 (e-mail: firstname.lastname@example.org).
Received March 1, 2019
Accepted July 14, 2019
Online date: July 19, 2019