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Electron Microscopic Evidence of Photoreceptor Outer-segments in the Trabecular Meshwork in a Case of Schwartz-Matsuo Syndrome

Clark, Antony MBBS, PhD*; Alkhotani, Alaa MD; Yucel, Yeni H. MD, PhD*,†,‡; Sylvester, Carly MD*; Kertes, Peter J. MD, CM*; Birt, Catherine M. MA, MD*

doi: 10.1097/IJG.0000000000001311
Case Report/Small Case Series

Purpose: To describe a case of photoreceptor outer segment glaucoma (Schwartz-Matsuo syndrome) with electron microscopic evidence of photoreceptor outer segments in the trabecular meshwork (TM).

Design: This is a clinicopathologic case report.

Participant: A 48-year-old Filipino man.

Methods: Specimens of aqueous humor and TM in a clinical case of Schwartz-Matsuo syndrome were examined by electron microscopy.

Main Outcome Measures: Electron photomicroscopy.

Results: Electron microscopy showed evidence of retinal photoreceptor outer-segments in both an aqueous humor and a TM specimen.

Conclusion: Schwartz-Matsuo syndrome is associated with the presence of photoreceptor outer segments in the TM.

Departments of *Ophthalmology and Vision Sciences

Laboratory Medicine and Pathobiology, University of Toronto

Department of Ophthalmology and Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, ON, Canada

Disclosure: The authors declare no conflict of interest.

Reprints: Catherine M. Birt, MA, MD, M1 302a, 2075 Bayview Ave., Toronto, ON, Canada M4N 3M5 (e-mail:

Received June 4, 2019

Accepted June 9, 2019

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