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Premature Expression of Pseudoexfoliation Syndrome With Presenile Cataract in a 28-Year-Old Lady

Kumar, Praveen S. MS*; Rao, Aparna MD; Senthil, Sirisha FRCS*

doi: 10.1097/IJG.0000000000001219
Online Articles: Case Report/Small Case Series

Purpose: We report a case of premature expression of pseudoexfoliation syndrome with presenile cataract in a 28-year-old lady with primary developmental glaucoma who had undergone glaucoma filtration surgery 26 years ago.

Methods/Results: We report a case of a 28-year-old Indian lady with progressive diminution of vision associated with photophobia in the left eye for 5 years and loss of vision in the right eye since childhood. She underwent glaucoma filtration surgery in the left eye at the age of 2 and was on 2 topical glaucoma medications when she presented to us. Refractive error was −17.00 D with −3.50 D @ 90-degree cylinder in the left eye. The right eye was phthisical. Left eye showed superior diffuse bleb, enlarged but clear cornea with superior Haab’s striae, deep and quiet anterior chamber and patent surgical iridectomy at 1 o’clock position. There was diffuse iris atrophy with pseudoexfoliation at the pupillary ruff and over the anterior lens capsule. Lens showed grade 2 nuclear cataract. Intraocular pressure in the left eye was 23 mm Hg. Fundus examination showed 0.9 cupping with an inferior notch and diffuse pallor of the optic disc. Axial length of left eye was 31.44 mm. On the basis of these findings, she was diagnosed with primary developmental glaucoma and high myopia, status after glaucoma filtration surgery with presenile cataract and pseudoexfoliation in the left eye. The topical antiglaucoma medications were augmented. After 1 month, intraocular pressure in the left eye was reduced to 14 mm Hg. She was advised to continue topical glaucoma medications and regular follow-up.

Conclusions: The present case is the first to describe the unusual presentation of pseudoexfoliation in a young individual along with presenile cataract. Simultaneous occurrence of pseudoexfoliation with cataract could be due to previous intraocular surgery, iris trauma, possible low-grade inflammation, and high myopia in a predisposed eye. The clinician should be aware that although a rare condition, pseudoexfoliation can occur in the young and may be associated with presenile cataract.

*L V Prasad Eye Institute, Banjara Hills, Hyderabad

L V Prasad Eye Institute, Patia Road, Bhubaneswar, India

Supported by Hyderabad Eye Research Foundation.

Disclosure: The authors declare no conflict of interest.

Reprints: Sirisha Senthil, FRCS, Road No. 2, Banjara Hills, L V Prasad Eye Institute, Hyderabad 500034, India (e-mails:;

Received December 4, 2018

Accepted February 9, 2019

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