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Patient-reported Outcomes, Functional Assessment, and Utility Values in Glaucoma

Skalicky, Simon E., FRANZCO, PhD*,†; Lamoureux, Ecosse L., MSc, PhD‡,§; Crabb, David P., MSc, PhD; Ramulu, Pradeep Y., MD, MHS, PhD

doi: 10.1097/IJG.0000000000001155

In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Standardizing and improving methods of patient-centered data collection and analysis in glaucoma studies are imperative. This paper outlines recommendations and provides a discussion of some of the pertinent issues relating to the optimization of patient-reported outcomes research in glaucoma.

*Department of Surgery, University of Melbourne

Discipline of Ophthalmology, University of Sydney, Australia

Singapore Eye Research Institute

§Duke NUS Medical School, Singapore

Optometry and Visual Science, School of Health Sciences, University of London, Northampton Square, London

Johns Hopkins Wilmer Eye Institute, MD

Disclosure: The authors declare no conflict of interest.

Reprints: Simon E. Skalicky, FRANZCO, PhD, 32 Gisborne St East, Melbourne, Victoria 3002, Australia (e-mail:

Received August 13, 2018

Accepted November 9, 2018

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