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Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?

Wolosin, J. Mario PhD*; Ritch, Robert MD; Bernstein, Audrey M. PhD*,‡

doi: 10.1097/IJG.0000000000000606
Original Studies

In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.

Departments of *Ophthalmology

Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai

Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY

Supported by The Research to Prevent Blindness, The MYS Family US Charitable Foundation Inc., The Bright Focus Foundation, and The Glaucoma Foundation (A.M.B. and J.M.W.), NIH-NEI R01 EY024942 (A.M.B.), and NIH-NEI R01 EY018748 (J.M.W.).

Disclosure: The authors declare no conflict of interest.

Reprints: J. Mario Wolosin, PhD, Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029 (e-mail:

Received September 29, 2016

Accepted November 9, 2016

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