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Do Intraocular Pressure Measurements Under Anesthesia Reflect the Awake Condition?

Gofman, Nina MD; Cohen, Barak MD; Matot, Idit MD; Cattan, Anat MSc; Dotan, Gad MD; Stolovitch, Chaim MD; Ela-Dalman, Noa MD

doi: 10.1097/IJG.0000000000000355
Original Studies

Background: Anesthesia or sedation is needed when intraocular pressure (IOP) measurement is required in certain circumstances. The effect of different anesthetic regimens on the IOP is still debatable. We aimed to evaluate alterations in the IOP under anesthesia with either propofol or different end-tidal concentrations of sevoflurane, when compared with the awake state.

Methods: The IOP was measured in both eyes of 20 adult patients undergoing extraocular ophthalmic surgeries at 5 timepoints: before the induction of general anesthesia (under topical anesthesia), after the induction using propofol target-controlled infusion, and under 3 end-tidal concentrations of sevoflurane (0.5%, 2%, and 5%), either in a decreasing (group A) or an increasing (group B) concentration order.

Results: With either propofol or sevoflurane anesthesia, the IOP did not differ significantly from the measurement performed during the awake state (no anesthesia), regardless of the concentration of sevoflurane used (in the range of 0.5% to 5%) or the order of sevoflurane administration (from low to high concentration or vice versa).

Conclusions: These data suggest that propofol and sevoflurane are valid anesthetic agents for the evaluation of IOP in adults when anesthesia is needed.

*Division of Anesthesia, Pain and Critical Care

Department of Ophthalmology, Tel-Aviv Medical Center Affiliated with Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel

Disclosure: The authors declare no conflict of interest.

Reprints: Barak Cohen, MD, Division of Anesthesia, Pain and Critical Care, Tel Aviv Medical Center, 6 Weitzman Street, Tel Aviv 64239, Israel (e-mail:

Received January 7, 2015

Accepted October 9, 2015

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