Original StudiesAb Interno Trabeculectomy With the Trabectome as a Valuable Therapeutic Option for Failed Filtering BlebsWecker, Thomas MD; Neuburger, Matthias MD; Bryniok, Laura; Bruder, Kathrin; Luebke, Jan MD; Anton, Alexandra MD; Jordan, Jens F. MDAuthor Information Eye Center, University of Freiburg, Freiburg, Germany Disclosure: The authors declare no conflict of interest. Reprints: Thomas Wecker, MD, Eye Center, University of Freiburg, Killianstraße 5, Freiburg 79106, Germany (e-mail: [email protected]). Journal of Glaucoma: September 2016 - Volume 25 - Issue 9 - p 758-762 doi: 10.1097/IJG.0000000000000492 Buy Metrics Abstract Purpose: Uncontrolled intraocular pressure (IOP) after glaucoma filtration surgery is a challenging problem in the management of glaucoma patients. The Trabectome is a device for selective electroablation of the trabecular meshwork through a clear cornea incision without affecting the conjunctiva. Minimally invasive glaucoma surgery using the Trabectome is safe and effective as primary glaucoma surgery. Here we investigate the results of ab interno trabeculectomy with the Trabectome for IOP control in patients with a failed filtering bleb. Methods: A total of 60 eyes of 60 consecutive patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PXG) were enrolled in this single center observational study. Trabectome surgery was performed alone or in combination with phacoemulsification by 2 experienced surgeons. IOP readings and number of IOP lowering medication as primary outcome parameters were taken by an independent examiner. Intraoperative and postoperative medication were recorded systematically. Results: Mean IOP before surgery was 24.5±3.5 mm Hg and decreased to 15.7±3.4 (−36%) after mean follow-up of 415 days. The number of necessary IOP lowering medication dropped from 2.1±1.3 to 1.8±1.2 (14% reduction from baseline). A total of 25% (n=15) of cases reported here needed additional surgery after 517 days (range: 6 to 1563 d). No major complications were observed. After mean follow-up, we found a qualified success rate for PXG of 87% and 50% for POAG as revealed by the Kaplan-Meier analysis according to the definitions for success in advanced glaucoma cases according to the World Glaucoma Association (40% reduction from baseline IOP and maximum IOP of 15 mm Hg). Discussion: Trabectome surgery for uncontrolled IOP after trabeculectomy is safe and effective especially in PXG patients. Given the demanding subgroup of patients studied here, it is not surprising that success rates are lower compared with previous studies investigating the Trabectome for primary glaucoma surgery. The number of necessary IOP lowering medication drops at first, but seems to reach preoperative values after 20 months of follow-up. Trabectome surgery should be considered as a valuable escape procedure for patients with failed filtering blebs and uncontrolled IOP. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.