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Meta-Analysis of Association of Obstructive Sleep Apnea With Glaucoma

Liu, Shulin MD*; Lin, Yu BS; Liu, Xin BS

doi: 10.1097/IJG.0000000000000357
Original Studies

Objectives: Previous studies suggested that obstructive sleep apnea (OSA) was associated with glaucoma. However, data on this issue are controversial. This study aims to use meta-analysis to determine whether OSA is related to glaucoma.

Materials and Methods: We searched PubMed, Embase, the Cochrane library, the Web of Science, and the Chinese BioMedical Literature Database disk databases up to November 20, 2014 for related literature. The association of OSA with glaucoma was assessed by odds ratio (OR) with 95% confidence interval (CI) as the effect size. Then subgroup analysis was performed according to area and glaucoma type.

Results: Six primary studies (3 cohort study and 3 case-control studies) were included in this meta-analysis involving 2,288,701 participants. There was a significant association between OSA and glaucoma (adjusted-effect summary for case-control studies OR=2.46; 95% CI, 1.32-4.59, P=0.005) (adjusted-effect summary for cohort studies OR=1.43; 95% CI, 1.21-1.69, P=0.000). There was no significant publication bias.

Conclusion: OSA was a risk factor for glaucoma. A large number of studies is needed to explore the mechanisms that link OSA with glaucoma.

*Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, The First Affiliated Hospital of Chongqing Medical University

Departments of Traditional Chinese Medicine

Clinical Pharmacy, Chongqing Medical University, Chongqing, China

S.L. and Y.L. are cofirst authors.

S.L. and X.L.: participated in study design. S.L. and Y.L.: participated in data acquisition, data analysis, and preparation of the manuscript. X.L.: gave instructions in statistical analysis. S.L., Y.L., and X.L.: participated in data interpretation, and critical revision and editing of the manuscript.

Supported by National Key Clinical Specialties Construction Program of China.

Disclosure: The authors declare no conflict of interest.

Reprints: Xin Liu, BS, Department of Clinical Pharmacy, Chongqing Medical University, 1 Yi Xue Yuan Road, Yu Zhong District, Chongqing 400016, China (e-mail:

Received February 26, 2015

Accepted October 11, 2015

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