Case ReportsThe Trabectome as Treatment Option in Secondary Glaucoma Due to Intraocular Lymphomavan Oterendorp, Christian MD, FEBO*; Ness, Thomas MD*; Illerhaus, Gerald MD†; Neuburger, Matthias MD*; Jordan, Jens F. MD*Author Information *University Eye Hospital †Department of Hematology and Oncology, University Hospital Medical Center, Freiburg, Germany Disclosure: The authors declare no conflict of interest. Reprints: Christian van Oterendorp, MD, FEBO, University Eye Hospital Freiburg, Killianstr. 5, 79106 Freiburg, Germany (e-mail: [email protected]). Received April 2, 2012 Accepted October 9, 2012 Journal of Glaucoma: September 2014 - Volume 23 - Issue 7 - p 482-484 doi: 10.1097/IJG.0b013e31827a0875 Buy Metrics Abstract Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell debris. We report on a case of severe IOP elevation after intraocular therapy with methotrexate and rituximab. As medical glaucoma therapy failed, a trabeculotomy with the trabectome was performed, leading to an immediate and sustained decrease in IOP. This novel approach is discussed considering pathogenic aspects of lymphoma-associated glaucoma and alternative surgical techniques. © 2014 by Lippincott Williams & Wilkins.