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Does Intravitreal Injections of Bevacizumab for Age-related Macular Degeneration Affect Long-term Intraocular Pressure?

Kim, Dongwook MD; Nam, Woo Ho MD; Kim, Ha Kyoung MD, PhD; Yi, Kayoung MD, PhD

doi: 10.1097/IJG.0b013e3182946505
Original Studies
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Purpose: To evaluate the long-term intraocular pressure (IOP) changes after intravitreal injection of bevacizumab for age-related macular degeneration.

Patients and Methods: A total of 83 eyes that received intravitreal injections of bevacizumab for age-related macular degeneration were enrolled. IOP measurements at baseline, 6, 12, 18, and 24 months, and at the last follow-up after injection were analyzed. On the basis of the median number of injections, the changes in IOP were compared.

Results: The mean number of injections was 3.71±1.62. There was no significantly higher elevation than baseline IOP (14.11±2.76 mm Hg) after multiple intravitreal injections of bevacizumab (P>0.05). In the group which had ≥4 injections, mean IOP measurements were not higher compared with the group which had <4 injections during the follow-up period (P>0.05). In the patients with preexisting glaucoma (3 eyes), there were no significant increases of IOP during the follow-up period.

Conclusions: IOP elevation was not observed during the long-term follow-up period. In addition, the numbers of injection and preexisting glaucoma did not affect IOP changes.

Department of Ophthalmology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea

K.Y.: design of the study; D.K., W.H.N., H.K.K., and K.Y.: collection and management of data; D.K. and K.Y.: analysis and interpretation of the data; D.K., W.H.N., H.K.K., and K.Y.: preparation of the manuscript and statistical analysis and interpretation; D.K., W.H.N., H.K.K., and K.Y.: review and approval of the manuscript.

This study was approved by the Institutional Review Board at Kangnam Sacred Heart Hospital and adhered to the Declaration of Helsinki. Informed consent was obtained from each participant.

Disclosure: The authors declare no conflict of interest.

Reprints: Kayoung Yi, MD, PhD, Department of Ophthalmology Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, 948-1 Daerim1-dong, Youngdeungpo-gu, Seoul 150-950, Korea (e-mail: kayoungyi@yahoo.co.kr).

Received June 25, 2012

Accepted February 2, 2013

© 2014 by Lippincott Williams & Wilkins.